rs16986953

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

coronary artery disease

Aragam KG et al. “Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.” Nature Genetics 54(12):1803-1815 (2022)
Allele A
OR 1.09
p 7.0e-20
N 1,165,690
Large GWAS
European, NR
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele A
OR 0.03
p 2.0e-9
N 640,258
Large GWAS
European, East Asian
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.07
p 6.0e-18
N 417,274
Major Consortium StudyLarge GWAS
European
Zhou W et al. “Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.” Nature Genetics 50(9):1335-1341 (2018)
Allele A
OR —
p 1.0e-8
N 408,458
Large GWAS
European
Matsunaga H et al. “Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease.” Circulation. Genomic and Precision Medicine 13(3):e002670 (2020)
Allele A
OR 1.10
p 1.0e-13
N 392,241
Meta-analysisLarge GWAS
multi-ancestry
van der Harst P et al. “Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.” Circulation Research 122(3):433-443 (2018)
Allele A
OR 0.09
p 1.0e-15
N 296,525
Large GWAS
Nikpay M et al. “A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.” Nature Genetics 47(10):1121-1130 (2015)
Allele A
OR 1.09
p 1.0e-8
N 187,599
Meta-analysisLarge GWAS
multi-ancestry
Nelson CP et al. “Association analyses based on false discovery rate implicate new loci for coronary artery disease.” Nature Genetics 49(9):1385-1391 (2017)
Allele A
OR 1.11
p 5.0e-10
N 63,731
Large GWAS
European, NR

coronary atherosclerosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.08
p 2.0e-19
N 424,341
Major Consortium StudyLarge GWAS
European

heart disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.08
p 9.0e-15
N 429,794
Major Consortium StudyLarge GWAS
European

myocardial infarction

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.09
p 2.0e-13
N 623,029
Large GWAS
multi-ancestry
Hartiala JA et al. “Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.” European Heart Journal 42(9):919-933 (2021)
Allele A
OR 1.09
p 4.0e-11
N 639,221
Large GWAS
multi-ancestry

Vasodilators used in cardiac diseases use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.08
p 1.0e-10
N 421,385
Large GWAS
multi-ancestry

angina pectoris

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.07
p 6.0e-10
N 630,096
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Association study of genetic variants at TTC32‐WDR35 gene cluster with coronary artery disease in Chinese Han population
AssociationN=1,870Ying Xu et al.(2021)· Journal of Clinical Laboratory Analysis

A case-control study in 935 Chinese Han CAD patients and 935 matched controls found that rs721932 CG genotype was associated with reduced CAD risk (OR=0.68, 95% CI: 0.54-0.86, P=0.001), while rs12617744 AA genotype was associated with CAD risk in males (OR=0.62, 95% CI: 0.42-0.93, P=0.02). Both SNPs were associated with HDL levels and disease severity markers including vascular lesion numbers and CAD progression.

Traits studied:CAD severityCoronary artery diseaseHDL cholesterolMyocardial infarctionVascular lesions
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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