FHL5

four and a half LIM domains 5

Summary

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

Known Variants18 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37982936:97,033,370A/Gintron variant
rs673382276:97,042,147A/Tintron variant
rs7589921476:97,051,500C/Tuncertain significance
rs24827887296:97,051,587A/Tuncertain significance
rs7703817886:97,052,645G/Tuncertain significance
rs13310266426:97,052,726G/Auncertain significance
rs5400800326:97,052,789C/Auncertain significance
rs17712405396:97,052,796G/Tuncertain significance
rs7628254796:97,053,783C/Tuncertain significance
rs7803030666:97,053,854A/Guncertain significance
rs77416836:97,054,493A/Gintron variant
rs77757216:97,056,979C/Tintron variant
rs3698968466:97,058,533G/Cuncertain significance
rs24828071896:97,058,548T/Cuncertain significance
rs7548286566:97,058,559G/Auncertain significance
rs94867156:97,059,769A/Cintron variant
rs24828192976:97,063,566C/Auncertain significance
rs117597696:97,065,212G/Adownstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.