FLRT2
fibronectin leucine rich transmembrane protein 2
Summary
This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs151074409 | 14:86,020,736 | C/T | intron variant | — |
| rs17712080 | 14:86,041,160 | G/A | intron variant | — |
| rs2746995 | 14:86,065,407 | T/C | — | — |
| rs146363556 | 14:86,079,893 | C/T | intron variant | — |
| rs777211965 | 14:86,087,940 | T/G | — | uncertain significance |
| rs200776611 | 14:86,088,051 | G/A | — | uncertain significance |
| rs2503599276 | 14:86,088,148 | G/T | — | uncertain significance |
| rs554986569 | 14:86,088,226 | C/T | — | uncertain significance |
| rs142516343 | 14:86,088,255 | T/G | — | uncertain significance |
| rs777746741 | 14:86,088,384 | G/T | — | uncertain significance |
| rs376157982 | 14:86,088,454 | C/T | — | uncertain significance |
| rs1048438509 | 14:86,088,517 | G/C | — | uncertain significance |
| rs759218903 | 14:86,088,532 | C/T | — | uncertain significance |
| rs1199413737 | 14:86,088,567 | A/T | — | uncertain significance |
| rs777515859 | 14:86,088,586 | C/T | — | uncertain significance |
| rs768174334 | 14:86,088,660 | C/T | — | uncertain significance |
| rs1049827519 | 14:86,088,667 | C/T | — | uncertain significance |
| rs1406545941 | 14:86,088,684 | C/T | — | uncertain significance |
| rs181491350 | 14:86,088,697 | G/A | — | uncertain significance |
| rs1342192331 | 14:86,088,780 | C/T | — | uncertain significance |
| rs17121377 | 14:86,088,848 | A/G | — | benign |
| rs1566763418 | 14:86,088,970 | C/T | — | uncertain significance |
| rs137990800 | 14:86,089,032 | A/G | — | likely benign |
| rs1014385948 | 14:86,089,056 | C/G | — | uncertain significance |
| rs369153024 | 14:86,089,057 | C/T | — | uncertain significance |
| rs149180602 | 14:86,089,078 | C/T | — | uncertain significance |
| rs139260862 | 14:86,089,243 | T/C | — | uncertain significance |
| rs1178681428 | 14:86,089,267 | T/G | — | uncertain significance |
| rs141004276 | 14:86,089,275 | G/A | — | uncertain significance |
| rs775518264 | 14:86,089,287 | C/T | — | uncertain significance |
| rs267604073 | 14:86,089,363 | G/A | — | uncertain significance |
| rs892978595 | 14:86,089,426 | G/A | — | uncertain significance |
| rs1316261526 | 14:86,089,453 | C/A | — | uncertain significance |
| rs567090913 | 14:86,089,489 | C/T | — | uncertain significance |
| rs201981148 | 14:86,089,507 | C/T | — | uncertain significance |
| rs1004692155 | 14:86,089,525 | T/C | — | uncertain significance |
| rs775899415 | 14:86,089,570 | G/A | — | uncertain significance |
| rs1893512817 | 14:86,089,629 | G/T | — | uncertain significance |
| rs751398044 | 14:86,089,762 | A/G | — | uncertain significance |
| rs2503607242 | 14:86,089,793 | G/A | — | uncertain significance |
| rs10483981 | 14:86,119,802 | C/T | intergenic variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.