FLT3LG
fms related receptor tyrosine kinase 3 ligand
Summary
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2946871 | 19:49,977,458 | C/G | regulatory region variant | — |
| rs2513970168 | 19:49,977,901 | C/T | — | likely benign |
| rs75750998 | 19:49,977,929 | A/G | — | benign |
| rs139145933 | 19:49,978,979 | C/T | — | uncertain significance |
| rs1195581012 | 19:49,979,723 | G/A | — | uncertain significance |
| rs766783205 | 19:49,979,735 | G/A | — | uncertain significance |
| rs752160204 | 19:49,979,779 | C/G | — | uncertain significance |
| rs755598105 | 19:49,979,780 | G/A | — | uncertain significance |
| rs79058858 | 19:49,979,789 | C/T | missense variant | — |
| rs188922376 | 19:49,981,533 | G/A | intron variant | — |
| rs752351114 | 19:49,982,167 | C/G | — | uncertain significance |
| rs1451163505 | 19:49,982,242 | C/T | — | uncertain significance |
| rs12459169 | 19:49,983,068 | T/C | intron variant | — |
| rs144504913 | 19:49,983,351 | G/A | intron variant | — |
| rs200009375 | 19:49,983,614 | G/T | — | uncertain significance |
| rs559855524 | 19:49,983,684 | G/A | — | uncertain significance |
| rs201160372 | 19:49,983,705 | G/A | — | uncertain significance |
| rs189355059 | 19:49,985,603 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.