rs79058858

This is a protein-altering variant in the FLT3LG gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

erythrocyte volume

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.15
p 1.0e-9
N 480,305
Large GWAS
multi-ancestry

mean corpuscular hemoglobin

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.14
p 9.0e-9
N 128,028
Large GWAS
East Asian

mosaic loss of chromosome Y measurement

Terao C et al. “GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation.” Nature Communications 10(1):4719 (2019)
Allele T
OR 0.16
p 1.0e-8
N 95,380
Large GWAS
East Asian

About FLT3LG

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

View all FLT3LG variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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