FOXN3
forkhead box N3
Summary
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2503506888 | 14:89,628,874 | T/A | — | uncertain significance |
| rs1887130945 | 14:89,628,934 | C/T | — | uncertain significance |
| rs201853361 | 14:89,628,994 | C/T | — | uncertain significance |
| rs45535535 | 14:89,629,001 | C/A | — | benign |
| rs375351484 | 14:89,629,013 | C/A | — | uncertain significance |
| rs369372657 | 14:89,629,053 | G/A | — | uncertain significance |
| rs763494456 | 14:89,629,185 | G/A | — | uncertain significance |
| rs542397192 | 14:89,629,293 | C/T | — | uncertain significance |
| rs185575747 | 14:89,631,928 | G/C | — | — |
| rs1411425961 | 14:89,656,737 | G/T | — | uncertain significance |
| rs17125516 | 14:89,666,734 | G/C | intron variant | — |
| rs769785124 | 14:89,747,336 | G/A | — | uncertain significance |
| rs112599894 | 14:89,776,559 | G/A | intron variant | — |
| rs60007302 | 14:89,798,069 | T/C | regulatory region variant | — |
| rs3825667 | 14:89,804,373 | T/A | regulatory region variant | — |
| rs573448077 | 14:89,826,465 | C/T | — | — |
| rs2008486 | 14:89,863,756 | A/C | upstream gene variant | — |
| rs753690270 | 14:89,878,293 | G/T | — | uncertain significance |
| rs754294736 | 14:89,878,675 | C/T | — | uncertain significance |
| rs1891564748 | 14:89,878,682 | C/G | — | uncertain significance |
| rs1891565176 | 14:89,878,694 | A/C | — | uncertain significance |
| rs139494967 | 14:89,878,697 | C/T | — | uncertain significance |
| rs772095230 | 14:89,878,702 | T/G | — | uncertain significance |
| rs2503391016 | 14:89,878,756 | A/C | — | uncertain significance |
| rs777712129 | 14:89,878,802 | G/A | — | uncertain significance |
| rs4904572 | 14:89,897,964 | T/A | — | — |
| rs8004664 | 14:90,034,972 | G/A | intron variant | — |
| rs242740 | 14:90,087,456 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.