GPD2

glycerol-3-phosphate dehydrogenase 2

Summary

The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

Known Variants54 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs553714328	2:157,332,646	C/T	—	uncertain significance
rs769907302	2:157,332,693	C/G	—	uncertain significance
rs2468519467	2:157,352,588	C/T	—	likely benign
rs145747966	2:157,352,676	A/G	—	conflicting classifications of pathogenicity
rs1057521483	2:157,352,686	G/A	—	uncertain significance
rs761600581	2:157,352,707	C/T	—	uncertain significance
rs297578	2:157,355,078	G/C	—	—
rs297587	2:157,356,460	A/G	—	—
rs297593	2:157,363,743	T/A	—	—
rs764546939	2:157,367,336	T/G	—	uncertain significance
rs1347634090	2:157,367,396	T/C	—	likely benign
rs141392427	2:157,368,740	G/A	—	uncertain significance
rs1003712146	2:157,369,876	A/G	—	uncertain significance
rs376931205	2:157,369,926	T/C	—	likely benign
rs116805380	2:157,369,927	G/A	—	benign
rs142821701	2:157,369,961	C/T	—	conflicting classifications of pathogenicity
rs769108865	2:157,369,963	A/G	—	uncertain significance
rs372524878	2:157,369,979	A/G	—	uncertain significance
rs752343390	2:157,370,000	A/G	—	uncertain significance
rs3769359	2:157,394,443	G/C	—	—
rs201094855	2:157,406,130	C/G	—	uncertain significance
rs370791262	2:157,406,131	G/A	—	uncertain significance
rs2468652155	2:157,406,216	T/C	—	uncertain significance
rs368542899	2:157,406,225	C/T	—	uncertain significance
rs1057522190	2:157,407,139	A/G	—	likely benign
rs769617848	2:157,407,168	C/G	—	uncertain significance
rs141792291	2:157,407,179	C/T	—	uncertain significance
rs773066241	2:157,407,180	G/A	—	uncertain significance
rs767842019	2:157,407,200	G/A	—	uncertain significance
rs116503732	2:157,407,209	A/G	—	likely benign
rs1316687280	2:157,407,210	T/A	—	uncertain significance
rs771535457	2:157,413,978	C/T	—	uncertain significance
rs1687008634	2:157,414,047	A/G	—	uncertain significance
rs1279553171	2:157,425,342	A/G	—	uncertain significance
rs762874223	2:157,425,395	C/G	—	likely benign
rs1302821503	2:157,425,411	C/G	—	uncertain significance
rs199775599	2:157,425,417	A/G	—	uncertain significance
rs200074868	2:157,426,009	C/A	—	uncertain significance
rs141790407	2:157,426,026	G/A	—	likely benign
rs146075516	2:157,426,048	G/A	—	uncertain significance
rs759884526	2:157,426,617	G/A	—	conflicting classifications of pathogenicity
rs2468707239	2:157,426,620	A/C	—	uncertain significance
rs936411977	2:157,426,655	G/C	—	uncertain significance
rs375974539	2:157,426,656	G/T	—	uncertain significance
rs139369525	2:157,426,695	C/T	—	uncertain significance
rs1687599242	2:157,427,682	G/A	—	uncertain significance
rs746390648	2:157,427,697	C/T	—	uncertain significance
rs1238540065	2:157,427,706	C/T	—	uncertain significance
rs116790305	2:157,427,763	C/G	—	likely benign
rs774528549	2:157,435,439	A/C	—	uncertain significance
rs765878694	2:157,435,479	T/C	—	uncertain significance
rs121918407	2:157,435,621	T/C	missense variant	pathogenic
rs767588356	2:157,439,331	G/C	—	uncertain significance
rs747731520	2:157,439,392	G/A	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.