GRIA3
glutamate ionotropic receptor AMPA type subunit 3
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Known Variants410 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs746204831 | X:122,317,820 | G/C | — | likely benign |
| rs374449092 | X:122,318,372 | T/C | — | benign |
| rs752728469 | X:122,318,389 | T/C | — | conflicting classifications of pathogenicity |
| rs781094406 | X:122,318,397 | C/A | — | uncertain significance |
| rs745873343 | X:122,318,398 | A/T | — | likely benign |
| rs1457703957 | X:122,318,401 | A/C | — | uncertain significance |
| rs61740996 | X:122,318,402 | G/A | — | benign |
| rs2520418046 | X:122,318,407 | T/C | — | uncertain significance |
| rs2520418095 | X:122,318,413 | A/C | — | uncertain significance |
| rs779764392 | X:122,318,422 | T/C | — | uncertain significance |
| rs2520418302 | X:122,318,425 | G/A | — | uncertain significance |
| rs1443326387 | X:122,318,427 | G/A | — | uncertain significance |
| rs937720275 | X:122,318,429 | G/A | — | likely benign |
| rs140014006 | X:122,318,430 | G/A | — | conflicting classifications of pathogenicity |
| rs747644263 | X:122,318,442 | G/A | — | uncertain significance |
| rs896354134 | X:122,318,444 | C/A | — | likely benign |
| rs746285416 | X:122,318,451 | C/A | — | uncertain significance |
| rs2520418732 | X:122,318,453 | T/G | — | likely benign |
| rs1927197500 | X:122,318,455 | T/G | — | uncertain significance |
| rs759740734 | X:122,318,456 | G/A | — | conflicting classifications of pathogenicity |
| rs868658758 | X:122,318,460 | C/T | — | uncertain significance |
| rs2520418881 | X:122,318,463 | T/A | — | uncertain significance |
| rs765395672 | X:122,318,474 | A/T | — | likely benign |
| rs758469536 | X:122,318,491 | G/A | — | uncertain significance |
| rs764200669 | X:122,318,493 | A/G | — | conflicting classifications of pathogenicity |
| rs2147242884 | X:122,318,497 | G/A | — | uncertain significance |
| rs2520419213 | X:122,318,501 | G/A | — | uncertain significance |
| rs756076055 | X:122,318,502 | C/T | — | uncertain significance |
| rs779829666 | X:122,318,507 | G/C | — | likely benign |
| rs758668213 | X:122,318,511 | G/C | — | likely benign |
| rs780417148 | X:122,318,516 | C/T | — | likely benign |
| rs112616639 | X:122,318,770 | C/T | — | benign |
| rs376191681 | X:122,319,641 | T/A | — | likely benign |
| rs760547182 | X:122,319,667 | G/A | — | likely benign |
| rs200671864 | X:122,319,672 | C/T | — | likely benign |
| rs2147244054 | X:122,319,697 | G/C | — | uncertain significance |
| rs2520429257 | X:122,319,699 | G/A | — | uncertain significance |
| rs1362682009 | X:122,319,706 | A/T | — | likely benign |
| rs754693937 | X:122,319,721 | C/T | — | likely benign |
| rs1927257518 | X:122,319,724 | T/C | — | likely benign |
| rs1298313682 | X:122,319,727 | C/T | — | likely benign |
| rs145583732 | X:122,319,733 | T/G | — | uncertain significance |
| rs758158942 | X:122,319,736 | C/T | — | conflicting classifications of pathogenicity |
| rs1927258484 | X:122,319,737 | G/A | — | uncertain significance |
| rs770034691 | X:122,319,796 | C/T | — | likely benign |
| rs1927261779 | X:122,319,806 | T/A | — | uncertain significance |
| rs1385977522 | X:122,319,823 | T/C | — | likely benign |
| rs2520430494 | X:122,319,827 | T/C | — | uncertain significance |
| rs1456555180 | X:122,319,829 | C/T | — | likely benign |
| rs774614482 | X:122,319,850 | G/T | — | likely benign |
| rs2269551 | X:122,319,917 | T/C | — | benign |
| rs73229252 | X:122,320,013 | T/A | — | benign |
| rs1927781157 | X:122,336,633 | G/A | — | uncertain significance |
| rs989638 | X:122,373,107 | C/G | — | — |
| rs3747322 | X:122,386,936 | A/G | — | benign |
| rs182532947 | X:122,387,013 | G/T | — | likely benign |
| rs2520692220 | X:122,387,134 | T/C | — | likely benign |
| rs2147282593 | X:122,387,135 | T/C | — | likely benign |
| rs1271388862 | X:122,387,164 | G/A | — | likely benign |
| rs2044401272 | X:122,387,169 | C/T | — | likely benign |
| rs368530347 | X:122,387,170 | G/A | — | likely benign |
| rs764021250 | X:122,387,172 | G/C | — | uncertain significance |
| rs2520692544 | X:122,387,192 | G/T | — | likely pathogenic |
| rs756957362 | X:122,387,213 | A/G | — | conflicting classifications of pathogenicity |
| rs746409680 | X:122,387,214 | T/C | — | uncertain significance |
| rs749960617 | X:122,387,221 | C/A | — | likely benign |
| rs766567391 | X:122,387,227 | C/T | — | benign |
| rs2147282636 | X:122,387,241 | C/T | — | uncertain significance |
| rs751876024 | X:122,387,254 | C/T | — | likely benign |
| rs755309623 | X:122,387,263 | G/A | — | likely benign |
| rs148560712 | X:122,387,264 | C/G | — | uncertain significance |
| rs2520692967 | X:122,387,273 | C/T | — | uncertain significance |
| rs142947328 | X:122,387,275 | C/T | — | likely benign |
| rs192636764 | X:122,387,281 | C/T | — | likely benign |
| rs151086692 | X:122,387,282 | G/A | — | conflicting classifications of pathogenicity |
| rs1297105927 | X:122,387,285 | G/A | — | uncertain significance |
| rs772661218 | X:122,387,287 | T/C | — | likely benign |
| rs371539507 | X:122,387,288 | G/A | — | uncertain significance |
| rs2520693105 | X:122,387,292 | A/G | — | uncertain significance |
| rs771205448 | X:122,387,304 | A/G | — | conflicting classifications of pathogenicity |
| rs775540855 | X:122,387,309 | C/T | — | uncertain significance |
| rs763033824 | X:122,387,310 | G/A | — | conflicting classifications of pathogenicity |
| rs1226381543 | X:122,387,311 | C/T | — | likely benign |
| rs1267207491 | X:122,387,315 | G/A | — | conflicting classifications of pathogenicity |
| rs1206751846 | X:122,387,321 | A/G | — | uncertain significance |
| rs986299564 | X:122,387,325 | G/A | — | uncertain significance |
| rs200503976 | X:122,387,326 | C/T | — | likely benign |
| rs761306897 | X:122,387,327 | G/A | — | uncertain significance |
| rs34670241 | X:122,387,329 | T/G | — | likely benign |
| rs2520693609 | X:122,387,343 | T/C | — | uncertain significance |
| rs144902457 | X:122,387,351 | T/C | missense variant | uncertain significance |
| rs1182591148 | X:122,387,356 | G/C | — | uncertain significance |
| rs2520693883 | X:122,387,373 | A/G | — | uncertain significance |
| rs2520693918 | X:122,387,375 | C/G | — | uncertain significance |
| rs1217897149 | X:122,387,380 | T/C | — | likely benign |
| rs2147282729 | X:122,387,397 | A/C | — | uncertain significance |
| rs755589194 | X:122,387,408 | C/T | — | likely benign |
| rs2520694220 | X:122,387,410 | G/A | — | likely benign |
| rs4825474 | X:122,387,642 | A/T | — | benign |
| rs1034428 | X:122,437,048 | A/C | — | — |
Showing 100 of 410 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.