rs989638
This variant is located in the GRIA3 gene.
▶Research that mentions this SNP (1)
▶Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patientsAssociationN=551Chiara Magri et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Case-control association study of AMPA receptor genes (GRIA2, GRIA3, GRIA4) in 551 Italian subjects (314 schizophrenia patients, 237 controls). No association found for GRIA2 and GRIA4. GRIA3 showed strong positive association with schizophrenia in females (rs1034428 A allele: OR=2.19, p<0.05; non-paranoid phenotype: OR=3.28), but not in males, indicating X-linked gender-specific susceptibility.
About GRIA3
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
View all GRIA3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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