GSTT2B
glutathione S-transferase theta 2B
Summary
The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs545554285 | 22:24,283,281 | C/T | — | likely benign |
| rs182254690 | 22:24,284,843 | G/A | — | likely benign |
| rs140196 | 22:24,299,403 | T/C | — | — |
| rs1622002 | 22:24,300,580 | C/T | missense variant | — |
| rs143373337 | 22:24,300,596 | C/T | — | uncertain significance |
| rs141411932 | 22:24,302,194 | G/C | — | — |
| rs781652428 | 22:24,302,485 | C/T | — | uncertain significance |
| rs200221229 | 22:24,303,001 | G/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.