HACL1
2-hydroxyacyl-CoA lyase 1
Summary
Enables several functions, including 2-hydroxyacyl-CoA lyase activity; ATP binding activity; and cation binding activity. Involved in fatty acid alpha-oxidation; phytanic acid metabolic process; and protein targeting to peroxisome. Located in nucleoplasm and peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs141479215 | 3:15,602,364 | G/A | — | likely benign |
| rs1050458050 | 3:15,602,376 | A/G | — | uncertain significance |
| rs149555880 | 3:15,604,875 | C/T | — | uncertain significance |
| rs140199501 | 3:15,604,876 | G/A | — | uncertain significance |
| rs186020952 | 3:15,604,955 | G/A | — | likely benign |
| rs574249207 | 3:15,605,003 | C/T | — | uncertain significance |
| rs368735834 | 3:15,605,022 | G/A | — | uncertain significance |
| rs754840690 | 3:15,605,041 | T/C | — | uncertain significance |
| rs751295536 | 3:15,606,063 | A/G | — | likely benign |
| rs145006644 | 3:15,609,385 | C/G | — | uncertain significance |
| rs1370500925 | 3:15,609,416 | C/A | — | uncertain significance |
| rs2271020 | 3:15,609,419 | T/C | — | likely benign |
| rs111333255 | 3:15,609,448 | C/A | — | likely benign |
| rs367905313 | 3:15,609,452 | A/C | — | likely benign |
| rs749988678 | 3:15,609,486 | G/C | — | uncertain significance |
| rs770308277 | 3:15,609,504 | T/C | — | uncertain significance |
| rs1384271381 | 3:15,609,505 | C/T | — | uncertain significance |
| rs2063471215 | 3:15,609,940 | T/C | — | uncertain significance |
| rs778910688 | 3:15,609,972 | C/T | — | uncertain significance |
| rs370023923 | 3:15,610,009 | C/T | — | uncertain significance |
| rs1210367121 | 3:15,610,023 | G/A | — | uncertain significance |
| rs905650 | 3:15,610,070 | T/C | — | benign |
| rs1424900334 | 3:15,610,980 | T/C | — | — |
| rs1306953234 | 3:15,610,989 | G/A | — | — |
| rs1336810492 | 3:15,610,993 | T/C | — | — |
| rs377248920 | 3:15,613,191 | T/C | — | uncertain significance |
| rs1574914663 | 3:15,613,255 | T/C | — | uncertain significance |
| rs41284033 | 3:15,614,707 | C/T | — | benign |
| rs755665986 | 3:15,614,740 | A/G | — | uncertain significance |
| rs776718184 | 3:15,616,557 | A/G | — | uncertain significance |
| rs770011516 | 3:15,616,569 | A/C | — | uncertain significance |
| rs2471085518 | 3:15,616,587 | G/T | — | uncertain significance |
| rs2471099727 | 3:15,621,421 | A/G | — | uncertain significance |
| rs149869846 | 3:15,621,459 | A/T | — | uncertain significance |
| rs376301747 | 3:15,621,475 | T/C | — | uncertain significance |
| rs200946097 | 3:15,621,501 | T/C | — | likely benign |
| rs567749845 | 3:15,621,555 | A/G | — | likely benign |
| rs139568574 | 3:15,624,419 | C/T | — | likely benign |
| rs75008576 | 3:15,624,436 | C/T | — | benign |
| rs568861263 | 3:15,624,463 | G/C | — | uncertain significance |
| rs367690435 | 3:15,624,486 | G/A | — | likely benign |
| rs1292734589 | 3:15,624,487 | T/A | — | uncertain significance |
| rs2063774664 | 3:15,626,799 | T/C | — | uncertain significance |
| rs748535962 | 3:15,626,830 | T/C | — | uncertain significance |
| rs368919972 | 3:15,626,839 | C/T | — | uncertain significance |
| rs74637339 | 3:15,628,040 | T/A | — | benign |
| rs374867050 | 3:15,628,115 | T/C | — | likely benign |
| rs73148185 | 3:15,635,116 | C/T | intron variant | — |
| rs146264180 | 3:15,637,903 | T/A | — | likely benign |
| rs759979137 | 3:15,637,913 | C/T | — | uncertain significance |
| rs146479983 | 3:15,642,601 | T/A | — | uncertain significance |
| rs1333528961 | 3:15,642,631 | C/T | — | uncertain significance |
| rs199662479 | 3:15,642,676 | A/T | — | uncertain significance |
| rs150277384 | 3:15,642,698 | C/T | — | uncertain significance |
| rs751795931 | 3:15,642,919 | T/C | — | uncertain significance |
| rs1170888518 | 3:15,642,956 | G/C | — | uncertain significance |
| rs748600989 | 3:15,642,959 | A/C | — | uncertain significance |
| rs773917314 | 3:15,642,963 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.