HDGFL2
HDGF like 2
Summary
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Known Variants13 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs140230395 | 19:4,482,657 | G/A | downstream gene variant | — |
| rs11672343 | 19:4,484,915 | G/A | intron variant | — |
| rs11085077 | 19:4,490,333 | C/T | intron variant | — |
| rs111174163 | 19:4,492,939 | T/G | — | — |
| rs770893579 | 19:4,493,809 | C/T | — | uncertain significance |
| rs200731789 | 19:4,493,990 | C/T | — | uncertain significance |
| rs1018908486 | 19:4,494,209 | G/A | — | uncertain significance |
| rs182131576 | 19:4,497,971 | C/T | — | uncertain significance |
| rs919798 | 19:4,498,154 | G/A | downstream gene variant | — |
| rs2288926 | 19:4,498,245 | A/T | — | — |
| rs1975797906 | 19:4,499,495 | G/A | — | uncertain significance |
| rs180870155 | 19:4,499,597 | A/G | — | likely benign |
| rs35632432 | 19:4,499,850 | G/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.