HIPK2
homeodomain interacting protein kinase 2
Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs56300656 | 7:139,259,895 | C/T | — | likely benign |
| rs1434981969 | 7:139,288,878 | G/A | — | uncertain significance |
| rs2030712 | 7:139,294,931 | C/A | — | — |
| rs2485817171 | 7:139,299,140 | C/T | — | uncertain significance |
| rs2485914802 | 7:139,311,454 | C/A | — | uncertain significance |
| rs67438121 | 7:139,332,533 | G/A | intron variant | — |
| rs141212865 | 7:139,404,666 | A/T | — | — |
| rs7456421 | 7:139,415,775 | G/C | synonymous variant | — |
| rs1795224647 | 7:139,415,867 | C/G | — | uncertain significance |
| rs1445967484 | 7:139,415,903 | C/T | — | uncertain significance |
| rs2486508023 | 7:139,416,064 | T/C | — | uncertain significance |
| rs760485579 | 7:139,416,363 | A/G | — | likely benign |
| rs780236493 | 7:139,416,509 | C/T | — | uncertain significance |
| rs1795257611 | 7:139,416,583 | A/G | — | uncertain significance |
| rs2486514929 | 7:139,416,603 | G/C | — | uncertain significance |
| rs2486517109 | 7:139,416,758 | A/T | — | uncertain significance |
| rs6952992 | 7:139,421,474 | C/G | regulatory region variant | — |
| rs7459106 | 7:139,439,007 | A/G | intron variant | — |
| rs4726459 | 7:139,459,895 | A/T | — | — |
| rs1011018 | 7:139,463,264 | G/A | regulatory region variant | — |
| rs28656273 | 7:139,467,676 | T/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.