HPGDS
hematopoietic prostaglandin D synthase
Summary
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs144419616 | 4:95,220,634 | G/C | — | benign |
| rs151209426 | 4:95,220,661 | C/G | — | uncertain significance |
| rs76328980 | 4:95,220,672 | C/T | — | benign |
| rs34124298 | 4:95,223,349 | A/G | — | benign |
| rs770974567 | 4:95,223,376 | A/G | — | uncertain significance |
| rs759548382 | 4:95,223,393 | C/G | — | likely benign |
| rs17021463 | 4:95,224,812 | T/G | intron variant | — |
| rs375827491 | 4:95,229,825 | A/G | — | uncertain significance |
| rs61752528 | 4:95,229,850 | T/C | — | benign |
| rs1756191908 | 4:95,229,880 | T/G | — | uncertain significance |
| rs4693382 | 4:95,231,997 | C/T | intron variant | — |
| rs9762154 | 4:95,232,067 | C/T | intron variant | — |
| rs766349696 | 4:95,239,065 | T/C | — | uncertain significance |
| rs116304230 | 4:95,246,677 | G/C | intron variant | — |
| rs933311564 | 4:95,255,672 | C/T | — | uncertain significance |
| rs762796539 | 4:95,255,699 | G/C | — | uncertain significance |
| rs148378201 | 4:95,255,739 | T/C | — | benign |
| rs11097414 | 4:95,260,301 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.