rs116304230

This is a intron variant variant in the HPGDS gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of glutathione-requiring prostaglandin D synthase in blood serum

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele C

OR 2.06

p 3.0e-30

N 466

Small GWAS

African American or Afro-Caribbean

About HPGDS

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

View all HPGDS variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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