HTR3A
5-hydroxytryptamine receptor 3A
Summary
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Known Variants57 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1150226 | 11:113,845,541 | A/G | regulatory region variant | — |
| rs1062613 | 11:113,846,006 | T/C | regulatory region variant | — |
| rs190646973 | 11:113,846,041 | G/T | — | benign |
| rs33940208 | 11:113,846,077 | C/T | synonymous variant | — |
| rs1456888 | 11:113,847,540 | C/T | intron variant | — |
| rs1985242 | 11:113,848,273 | A/C | intron variant | — |
| rs182799368 | 11:113,848,454 | G/T | intron variant | — |
| rs886296854 | 11:113,848,505 | G/A | — | uncertain significance |
| rs2548035476 | 11:113,848,557 | C/A | — | uncertain significance |
| rs572508628 | 11:113,848,561 | A/G | — | uncertain significance |
| rs866497878 | 11:113,848,592 | G/T | — | uncertain significance |
| rs770614768 | 11:113,848,601 | C/T | — | uncertain significance |
| rs200174404 | 11:113,848,641 | C/A | — | uncertain significance |
| rs747021831 | 11:113,849,995 | G/C | — | uncertain significance |
| rs61905785 | 11:113,850,006 | A/C | splice region variant | — |
| rs2276302 | 11:113,850,140 | G/T | — | — |
| rs79452715 | 11:113,852,043 | C/T | — | benign |
| rs369511862 | 11:113,852,044 | G/A | — | likely benign |
| rs1456887 | 11:113,853,470 | C/T | intron variant | — |
| rs143696508 | 11:113,853,843 | G/A | — | uncertain significance |
| rs750232510 | 11:113,853,853 | G/A | — | uncertain significance |
| rs150595107 | 11:113,853,875 | C/T | — | likely benign |
| rs139646314 | 11:113,853,876 | G/T | — | uncertain significance |
| rs149715642 | 11:113,853,886 | G/A | — | likely benign |
| rs778454392 | 11:113,853,891 | C/A | — | uncertain significance |
| rs145587443 | 11:113,853,897 | G/A | — | uncertain significance |
| rs1950444509 | 11:113,853,937 | G/A | — | uncertain significance |
| rs776085814 | 11:113,853,985 | T/G | — | uncertain significance |
| rs10160548 | 11:113,856,681 | G/C | — | — |
| rs2548039642 | 11:113,856,760 | T/C | — | uncertain significance |
| rs150244368 | 11:113,856,838 | C/T | — | uncertain significance |
| rs139246177 | 11:113,856,847 | C/T | — | likely benign |
| rs186301416 | 11:113,856,881 | C/G | — | uncertain significance |
| rs201381381 | 11:113,857,253 | G/A | — | uncertain significance |
| rs776946829 | 11:113,857,310 | T/C | — | uncertain significance |
| rs76963178 | 11:113,857,317 | C/T | — | benign |
| rs1432743814 | 11:113,857,333 | C/A | — | uncertain significance |
| rs141387942 | 11:113,857,347 | C/T | — | benign |
| rs377608018 | 11:113,857,421 | C/T | — | uncertain significance |
| rs1186180476 | 11:113,857,430 | C/T | — | uncertain significance |
| rs370293059 | 11:113,857,567 | A/G | — | uncertain significance |
| rs750245920 | 11:113,857,594 | G/A | — | uncertain significance |
| rs1950500178 | 11:113,857,640 | A/G | — | uncertain significance |
| rs141774545 | 11:113,857,645 | G/A | — | uncertain significance |
| rs368078447 | 11:113,857,659 | G/C | — | likely benign |
| rs182100593 | 11:113,857,660 | C/T | — | uncertain significance |
| rs746739129 | 11:113,857,736 | C/T | — | uncertain significance |
| rs1377796123 | 11:113,857,738 | T/C | — | uncertain significance |
| rs777508637 | 11:113,860,245 | G/A | — | likely benign |
| rs771908921 | 11:113,860,265 | C/G | — | uncertain significance |
| rs183698487 | 11:113,860,274 | G/A | — | benign |
| rs763868109 | 11:113,860,295 | G/A | — | uncertain significance |
| rs35944954 | 11:113,860,389 | C/T | — | benign |
| rs777809821 | 11:113,860,390 | G/A | — | uncertain significance |
| rs775045293 | 11:113,860,405 | C/G | — | uncertain significance |
| rs1176713 | 11:113,860,425 | A/G | synonymous variant | — |
| rs778095592 | 11:113,860,480 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.