ICOS

inducible T cell costimulator

Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

Known Variants159 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs11883722	2:204,800,845	G/A	upstream gene variant	—
rs576726896	2:204,801,514	G/T	—	uncertain significance
rs1360705806	2:204,801,546	A/C	—	likely benign
rs1689659275	2:204,801,550	C/T	—	uncertain significance
rs2469780660	2:204,801,554	G/A	—	pathogenic
rs1689659550	2:204,801,561	C/A	—	uncertain significance
rs77411896	2:204,801,577	C/T	—	benign
rs776057192	2:204,801,578	G/A	—	uncertain significance
rs765158675	2:204,801,579	C/A	—	conflicting classifications of pathogenicity
rs752669955	2:204,801,580	A/G	—	uncertain significance
rs762842725	2:204,801,582	T/G	—	uncertain significance
rs757598952	2:204,801,596	G/A	—	likely pathogenic
rs2105741117	2:204,801,599	A/C	—	uncertain significance
rs140049646	2:204,801,604	T/G	—	conflicting classifications of pathogenicity
rs780437269	2:204,801,608	T/C	—	likely benign
rs2469780799	2:204,801,615	T/G	—	likely benign
rs10932029	2:204,801,768	T/C	intron variant	benign
rs4675374	2:204,802,578	T/A	—	—
rs11571323	2:204,818,844	G/C	—	—
rs745431176	2:204,820,343	C/A	—	likely benign
rs2469806840	2:204,820,352	T/C	—	likely benign
rs764098873	2:204,820,356	C/T	—	uncertain significance
rs1015881666	2:204,820,361	G/T	—	pathogenic
rs774325808	2:204,820,371	G/T	—	uncertain significance
rs761695473	2:204,820,377	C/A	—	uncertain significance
rs977088960	2:204,820,385	G/A	—	uncertain significance
rs147754976	2:204,820,393	T/C	—	likely benign
rs1380258709	2:204,820,402	C/T	—	likely benign
rs201031378	2:204,820,405	C/T	—	conflicting classifications of pathogenicity
rs202109644	2:204,820,406	G/A	—	uncertain significance
rs1367837109	2:204,820,428	A/G	—	uncertain significance
rs1690065667	2:204,820,429	A/T	—	uncertain significance
rs55972840	2:204,820,450	A/G	—	benign
rs1291412174	2:204,820,463	T/C	—	likely benign
rs775111991	2:204,820,477	G/A	—	likely benign
rs886055496	2:204,820,484	C/T	—	uncertain significance
rs1553499319	2:204,820,486	C/T	—	likely benign
rs537195517	2:204,820,489	C/A	—	conflicting classifications of pathogenicity
rs1215466849	2:204,820,490	G/A	—	uncertain significance
rs2469807213	2:204,820,523	G/A	—	likely benign
rs1048198057	2:204,820,529	A/G	—	uncertain significance
rs2105754222	2:204,820,535	A/C	—	uncertain significance
rs555157948	2:204,820,549	C/T	—	likely benign
rs1314279149	2:204,820,571	A/G	—	uncertain significance
rs778146668	2:204,820,591	C/A	—	pathogenic
rs2105754276	2:204,820,594	C/T	—	likely benign
rs2105754294	2:204,820,618	T/G	—	pathogenic
rs1335754145	2:204,820,636	A/G	—	likely benign
rs1355757302	2:204,820,637	A/G	—	uncertain significance
rs375299065	2:204,820,656	T/C	—	conflicting classifications of pathogenicity
rs768500706	2:204,820,675	A/G	—	conflicting classifications of pathogenicity
rs2105754334	2:204,820,676	G/A	—	uncertain significance
rs2469807475	2:204,820,687	T/C	—	likely benign
rs1257110059	2:204,820,690	T/A	—	likely benign
rs1559035937	2:204,820,696	T/C	—	likely pathogenic
rs2105754340	2:204,820,701	C/T	—	likely benign
rs1482892394	2:204,820,703	T/C	—	likely benign
rs771786604	2:204,820,708	T/G	—	likely benign
rs773108522	2:204,820,711	A/G	—	likely benign
rs760358752	2:204,820,713	C/T	—	likely benign
rs7592421	2:204,821,079	G/T	—	benign
rs747590481	2:204,821,363	A/G	—	likely benign
rs772088014	2:204,821,364	C/A	—	likely benign
rs2105754735	2:204,821,367	T/C	—	likely benign
rs2469808283	2:204,821,378	C/A	—	likely benign
rs367905290	2:204,821,388	A/C	—	uncertain significance
rs776847112	2:204,821,389	A/G	—	likely benign
rs746054383	2:204,821,393	T/C	—	uncertain significance
rs1260496726	2:204,821,398	C/T	—	likely benign
rs2469808325	2:204,821,403	T/G	—	uncertain significance
rs2469808332	2:204,821,414	T/C	—	likely benign
rs139449630	2:204,821,425	A/T	—	likely benign
rs76778263	2:204,821,438	G/C	—	conflicting classifications of pathogenicity
rs1690083811	2:204,821,453	T/G	—	uncertain significance
rs754099136	2:204,821,458	A/G	—	likely benign
rs1690084220	2:204,821,464	A/G	—	uncertain significance
rs565719501	2:204,821,482	A/C	—	conflicting classifications of pathogenicity
rs1297706917	2:204,821,483	A/G	—	uncertain significance
rs1448022642	2:204,821,487	A/T	—	uncertain significance
rs4264550	2:204,821,494	C/G	—	uncertain significance
rs57149344	2:204,821,495	G/A	—	benign
rs770065338	2:204,821,500	C/T	—	likely benign
rs775673964	2:204,821,504	C/G	—	likely benign
rs11571313	2:204,821,605	C/T	—	benign
rs4270326	2:204,821,614	C/G	intron variant	benign
rs11571314	2:204,821,842	A/G	intron variant	—
rs10176404	2:204,822,265	A/G	—	benign
rs56236018	2:204,822,294	T/C	—	benign
rs55649217	2:204,822,409	C/T	—	benign
rs1581607452	2:204,822,522	A/C	—	uncertain significance
rs2105755520	2:204,822,529	C/T	—	uncertain significance
rs148435889	2:204,822,530	A/G	—	conflicting classifications of pathogenicity
rs780326986	2:204,822,532	C/A	—	uncertain significance
rs2105755531	2:204,822,534	A/G	—	uncertain significance
rs150573153	2:204,822,536	T/C	—	likely benign
rs376555288	2:204,822,542	C/T	—	likely benign
rs778908715	2:204,822,543	G/A	—	uncertain significance
rs748208335	2:204,822,545	C/T	—	likely benign
rs370645286	2:204,822,551	C/T	—	likely benign
rs2105755568	2:204,822,567	A/G	—	uncertain significance

Showing 100 of 159 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.