IL11
interleukin 11
Summary
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs545164548 | 19:55,877,382 | C/T | — | uncertain significance |
| rs766720309 | 19:55,877,383 | G/A | — | uncertain significance |
| rs201003688 | 19:55,877,410 | C/T | — | uncertain significance |
| rs756078236 | 19:55,877,427 | A/G | — | uncertain significance |
| rs749026700 | 19:55,877,436 | C/G | — | uncertain significance |
| rs779069587 | 19:55,877,437 | C/T | — | uncertain significance |
| rs1489469892 | 19:55,877,439 | C/T | — | uncertain significance |
| rs145194651 | 19:55,877,441 | C/A | — | benign |
| rs767003312 | 19:55,877,467 | C/A | — | uncertain significance |
| rs1297846668 | 19:55,877,488 | G/A | — | uncertain significance |
| rs772605494 | 19:55,877,518 | G/A | — | uncertain significance |
| rs778014138 | 19:55,879,592 | G/C | — | uncertain significance |
| rs553947830 | 19:55,879,594 | C/T | — | uncertain significance |
| rs757409297 | 19:55,879,595 | G/A | — | uncertain significance |
| rs1005633961 | 19:55,879,605 | G/T | — | uncertain significance |
| rs752519118 | 19:55,879,669 | C/T | — | uncertain significance |
| rs4252548 | 19:55,879,672 | C/T | missense variant | — |
| rs369342350 | 19:55,879,687 | T/A | — | uncertain significance |
| rs780671416 | 19:55,879,690 | C/T | — | uncertain significance |
| rs950285638 | 19:55,879,709 | C/G | — | uncertain significance |
| rs1442380870 | 19:55,879,715 | G/C | — | uncertain significance |
| rs1126757 | 19:55,879,872 | C/G | synonymous variant | — |
| rs141630906 | 19:55,879,913 | C/A | — | uncertain significance |
| rs767906633 | 19:55,880,223 | A/C | — | uncertain significance |
| rs754658079 | 19:55,880,232 | G/C | — | uncertain significance |
| rs1353193400 | 19:55,880,235 | G/A | — | likely benign |
| rs758437473 | 19:55,880,264 | G/C | — | likely benign |
| rs8104023 | 19:55,881,351 | T/G | — | — |
| rs80179286 | 19:55,882,040 | G/C | regulatory region variant | — |
| rs4252546 | 19:55,882,345 | T/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.