IL16
interleukin 16
Summary
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Known Variants111 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4505265 | 15:81,477,455 | A/C | — | — |
| rs4448892 | 15:81,489,063 | C/T | intron variant | — |
| rs1912124 | 15:81,498,971 | T/C | intron variant | — |
| rs759686946 | 15:81,517,748 | C/T | — | uncertain significance |
| rs750324638 | 15:81,517,759 | G/A | — | likely benign |
| rs756134523 | 15:81,517,763 | G/C | — | uncertain significance |
| rs1308801319 | 15:81,517,769 | G/T | — | uncertain significance |
| rs781648023 | 15:81,517,913 | A/C | — | uncertain significance |
| rs759476639 | 15:81,518,032 | A/G | — | uncertain significance |
| rs67093094 | 15:81,530,848 | C/T | intron variant | — |
| rs7172689 | 15:81,533,695 | C/T | intron variant | — |
| rs28648707 | 15:81,534,034 | G/A | intron variant | — |
| rs779390605 | 15:81,544,869 | A/C | — | — |
| rs560837446 | 15:81,552,213 | A/T | — | uncertain significance |
| rs779831651 | 15:81,558,066 | A/G | — | uncertain significance |
| rs201141132 | 15:81,558,119 | G/A | — | uncertain significance |
| rs7175701 | 15:81,558,623 | T/C | regulatory region variant | — |
| rs367852294 | 15:81,561,898 | G/A | — | uncertain significance |
| rs149850550 | 15:81,561,921 | G/A | — | uncertain significance |
| rs1898543769 | 15:81,561,931 | C/A | — | uncertain significance |
| rs776826431 | 15:81,565,449 | G/A | — | uncertain significance |
| rs781262096 | 15:81,565,516 | C/A | — | uncertain significance |
| rs188062582 | 15:81,565,527 | G/T | — | uncertain significance |
| rs58076056 | 15:81,567,576 | G/T | — | — |
| rs373562616 | 15:81,571,190 | A/G | — | uncertain significance |
| rs2542995923 | 15:81,571,914 | C/T | — | uncertain significance |
| rs770267179 | 15:81,571,939 | G/A | — | uncertain significance |
| rs537866391 | 15:81,571,945 | C/T | — | likely benign |
| rs1205938737 | 15:81,571,970 | C/A | — | uncertain significance |
| rs773455913 | 15:81,571,977 | C/T | — | uncertain significance |
| rs375892392 | 15:81,571,981 | C/T | — | uncertain significance |
| rs1307224297 | 15:81,572,011 | G/A | — | uncertain significance |
| rs202091691 | 15:81,572,053 | C/T | — | uncertain significance |
| rs765353678 | 15:81,572,070 | G/T | — | uncertain significance |
| rs201210766 | 15:81,572,094 | G/A | — | uncertain significance |
| rs756994663 | 15:81,574,985 | G/A | — | uncertain significance |
| rs773459097 | 15:81,575,015 | G/A | — | uncertain significance |
| rs780472079 | 15:81,575,048 | G/T | — | uncertain significance |
| rs746143844 | 15:81,578,049 | G/A | — | uncertain significance |
| rs768432125 | 15:81,578,050 | A/C | — | uncertain significance |
| rs747103573 | 15:81,578,130 | G/A | — | uncertain significance |
| rs4072111 | 15:81,578,139 | C/T | missense variant | — |
| rs1899423158 | 15:81,578,145 | A/G | — | uncertain significance |
| rs758544832 | 15:81,582,864 | A/G | — | uncertain significance |
| rs752638406 | 15:81,585,040 | G/C | — | uncertain significance |
| rs775433505 | 15:81,585,124 | C/T | — | uncertain significance |
| rs771552318 | 15:81,585,294 | A/C | — | uncertain significance |
| rs2543067961 | 15:81,585,374 | G/C | — | uncertain significance |
| rs17875486 | 15:81,586,063 | C/T | regulatory region variant | — |
| rs17875491 | 15:81,586,928 | G/T | — | — |
| rs4778889 | 15:81,588,995 | T/C | regulatory region variant | — |
| rs759090105 | 15:81,589,264 | C/A | — | likely benign |
| rs374151171 | 15:81,589,278 | G/C | — | uncertain significance |
| rs199946459 | 15:81,589,341 | G/A | — | likely benign |
| rs541690334 | 15:81,589,359 | A/G | — | likely benign |
| rs766682484 | 15:81,589,362 | G/C | — | uncertain significance |
| rs4778890 | 15:81,589,648 | C/G | regulatory region variant | — |
| rs770035791 | 15:81,591,736 | C/T | — | uncertain significance |
| rs373504063 | 15:81,591,758 | G/C | — | uncertain significance |
| rs753354581 | 15:81,591,768 | C/T | — | uncertain significance |
| rs773019059 | 15:81,591,840 | T/C | — | uncertain significance |
| rs142079015 | 15:81,591,851 | C/G | — | uncertain significance |
| rs2543102833 | 15:81,591,852 | A/G | — | uncertain significance |
| rs146704319 | 15:81,591,866 | T/C | — | likely benign |
| rs368198413 | 15:81,591,889 | A/T | — | uncertain significance |
| rs146879820 | 15:81,591,991 | A/G | — | uncertain significance |
| rs1232671785 | 15:81,592,026 | C/T | — | uncertain significance |
| rs758578332 | 15:81,592,119 | C/T | — | uncertain significance |
| rs778107899 | 15:81,592,125 | C/T | — | uncertain significance |
| rs373788174 | 15:81,592,240 | G/A | — | uncertain significance |
| rs1046094990 | 15:81,592,259 | C/G | — | likely benign |
| rs17875512 | 15:81,592,333 | G/A | — | benign |
| rs199597387 | 15:81,592,411 | G/C | — | uncertain significance |
| rs201457933 | 15:81,592,420 | G/A | — | uncertain significance |
| rs767842750 | 15:81,592,446 | C/T | — | uncertain significance |
| rs374702043 | 15:81,592,470 | C/G | — | uncertain significance |
| rs555572567 | 15:81,592,473 | C/G | — | uncertain significance |
| rs146341072 | 15:81,592,481 | G/A | — | benign |
| rs2543107471 | 15:81,592,488 | C/A | — | uncertain significance |
| rs139561765 | 15:81,592,489 | T/G | — | uncertain significance |
| rs144499024 | 15:81,592,548 | A/G | — | uncertain significance |
| rs144608313 | 15:81,592,560 | C/T | — | uncertain significance |
| rs2543108533 | 15:81,592,626 | C/G | — | uncertain significance |
| rs1034231395 | 15:81,592,699 | G/A | — | uncertain significance |
| rs34101586 | 15:81,592,746 | T/A | — | benign |
| rs140544740 | 15:81,592,756 | A/T | — | uncertain significance |
| rs373859330 | 15:81,592,774 | G/A | — | uncertain significance |
| rs572690852 | 15:81,592,792 | C/T | — | uncertain significance |
| rs11073001 | 15:81,592,802 | A/G | synonymous variant | — |
| rs202181184 | 15:81,593,738 | A/T | — | uncertain significance |
| rs112910065 | 15:81,593,757 | C/T | — | benign |
| rs190681666 | 15:81,593,818 | G/A | — | uncertain significance |
| rs8034928 | 15:81,594,123 | T/C | regulatory region variant | — |
| rs58754882 | 15:81,595,358 | G/A | — | — |
| rs3848180 | 15:81,596,590 | T/A | — | — |
| rs4577037 | 15:81,596,660 | T/G | regulatory region variant | — |
| rs17875532 | 15:81,598,110 | C/T | downstream gene variant | — |
| rs11556218 | 15:81,598,269 | T/G | missense variant | — |
| rs551302549 | 15:81,598,272 | G/A | — | benign |
| rs150362407 | 15:81,598,374 | C/A | — | likely benign |
Showing 100 of 111 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.