IL17RA

interleukin 17 receptor A

Summary

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Known Variants795 total

rsidPosition (GRCh37)AllelesClassClinVar
rs4143304522:17,564,478T/Cupstream gene variant—
rs481955422:17,565,035G/C——
rs56216570622:17,565,856C/G—benign
rs52929046522:17,565,887G/C—uncertain significance
rs1305369422:17,565,888A/C—benign
rs91786422:17,565,932T/C—benign
rs55169358722:17,565,940G/A—uncertain significance
rs77571903822:17,565,943C/T—uncertain significance
rs4152534422:17,565,949C/G—benign
rs88605719922:17,565,955C/G—uncertain significance
rs53720606422:17,565,959C/A—uncertain significance
rs91786522:17,565,974G/C—benign
rs92273053922:17,565,976C/G—likely benign
rs56732004122:17,565,989C/T—uncertain significance
rs135860378822:17,565,990C/A—likely benign
rs135133741322:17,565,994C/T—uncertain significance
rs206132113022:17,565,998G/A—uncertain significance
rs98875215122:17,565,999C/T—likely benign
rs53439949222:17,566,000C/T—conflicting classifications of pathogenicity
rs14365200222:17,566,001C/T—likely benign
rs212378657622:17,566,004C/T—uncertain significance
rs75240740322:17,566,007C/T—uncertain significance
rs57721733122:17,566,011T/A—conflicting classifications of pathogenicity
rs212378659422:17,566,014C/A—likely benign
rs88605720022:17,566,017G/T—conflicting classifications of pathogenicity
rs160133281422:17,566,022C/G—uncertain significance
rs206132148622:17,566,034T/C—uncertain significance
rs75775275322:17,566,035G/A—likely benign
rs142927025922:17,566,036C/T—uncertain significance
rs93790271022:17,566,037T/G—uncertain significance
rs141815068422:17,566,038C/T—likely benign
rs53978298222:17,566,045C/T—uncertain significance
rs4151084722:17,566,051G/C—uncertain significance
rs121698468622:17,566,053C/T—likely benign
rs129701615722:17,566,054G/C—uncertain significance
rs89628537422:17,566,056G/A—likely benign
rs149095542122:17,566,061C/A—uncertain significance
rs122277116622:17,566,062C/T—likely benign
rs148775684122:17,566,064C/T—uncertain significance
rs118836152822:17,566,065G/T—likely benign
rs144911257022:17,566,074C/T—likely benign
rs138727873422:17,566,081C/A—likely benign
rs88718860222:17,566,086C/G—likely benign
rs206132195922:17,566,087C/G—uncertain significance
rs147657368122:17,566,101G/C—likely benign
rs129503718922:17,566,102C/G—uncertain significance
rs135801550322:17,566,107C/T—likely benign
rs100607468622:17,566,114C/A—uncertain significance
rs118674913522:17,566,119G/A—uncertain significance
rs53428761122:17,566,131C/T—benign
rs212378687922:17,566,135G/A—likely benign
rs116133918622:17,566,137G/C—likely benign
rs227024122:17,566,206G/T—benign
rs227024222:17,566,229T/A—benign
rs1215921722:17,573,915G/Tdownstream gene variant—
rs206137084022:17,577,934A/C—likely benign
rs36948139322:17,577,936C/G—likely benign
rs86609797222:17,577,939C/G—likely benign
rs212379723922:17,577,946C/T—likely benign
rs115635290622:17,577,953G/A—uncertain significance
rs76453196022:17,577,955C/A—uncertain significance
rs18198705022:17,577,957A/G—likely benign
rs14300869622:17,577,965C/T—conflicting classifications of pathogenicity
rs76786056922:17,577,966G/A—likely benign
rs53884600822:17,577,975T/C—uncertain significance
rs212379729122:17,577,978T/C—likely pathogenic
rs251715882822:17,578,668G/C—likely benign
rs75666459522:17,578,689A/G—uncertain significance
rs75387854622:17,578,708G/A—pathogenic
rs133072393922:17,578,709G/A—pathogenic
rs105751874522:17,578,719C/Tstop gainedpathogenic
rs88605720122:17,578,722A/G—uncertain significance
rs251715893222:17,578,733C/G—likely benign
rs138916592822:17,578,736C/T—likely benign
rs75296441922:17,578,743A/G—uncertain significance
rs14319842322:17,578,746G/A—likely benign
rs74577481122:17,578,750T/C—uncertain significance
rs156891859322:17,578,751G/A—likely benign
rs160134099922:17,578,766C/T—likely benign
rs251715897822:17,578,769T/C—likely benign
rs20199692122:17,578,770G/A—uncertain significance
rs77208313522:17,578,773C/G—uncertain significance
rs77366687622:17,578,774A/G—uncertain significance
rs251715901122:17,578,779C/A—uncertain significance
rs55399931022:17,578,781A/G—likely benign
rs76682587522:17,578,782C/A—uncertain significance
rs78081742222:17,578,799C/T—likely benign
rs14749514622:17,578,800G/A—uncertain significance
rs251715906922:17,578,802G/A—likely benign
rs75599371022:17,578,804C/T—conflicting classifications of pathogenicity
rs74930640122:17,578,812G/A—uncertain significance
rs251715911222:17,578,815T/C—likely pathogenic
rs13995196622:17,578,820A/G—likely benign
rs20112823722:17,578,835T/C—likely pathogenic
rs77171968522:17,578,836G/A—uncertain significance
rs19964069322:17,578,842G/T—likely benign
rs77711522922:17,578,853G/A—likely benign
rs4139654722:17,579,054T/Cupstream gene variant—
rs130269696522:17,579,645C/G—likely benign
rs37183162322:17,579,647C/A—likely benign

Showing 100 of 795 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.