IL17RA

interleukin 17 receptor A

Summary

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Known Variants795 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs41433045	22:17,564,478	T/C	upstream gene variant	—
rs4819554	22:17,565,035	G/C	—	—
rs562165706	22:17,565,856	C/G	—	benign
rs529290465	22:17,565,887	G/C	—	uncertain significance
rs13053694	22:17,565,888	A/C	—	benign
rs917864	22:17,565,932	T/C	—	benign
rs551693587	22:17,565,940	G/A	—	uncertain significance
rs775719038	22:17,565,943	C/T	—	uncertain significance
rs41525344	22:17,565,949	C/G	—	benign
rs886057199	22:17,565,955	C/G	—	uncertain significance
rs537206064	22:17,565,959	C/A	—	uncertain significance
rs917865	22:17,565,974	G/C	—	benign
rs922730539	22:17,565,976	C/G	—	likely benign
rs567320041	22:17,565,989	C/T	—	uncertain significance
rs1358603788	22:17,565,990	C/A	—	likely benign
rs1351337413	22:17,565,994	C/T	—	uncertain significance
rs2061321130	22:17,565,998	G/A	—	uncertain significance
rs988752151	22:17,565,999	C/T	—	likely benign
rs534399492	22:17,566,000	C/T	—	conflicting classifications of pathogenicity
rs143652002	22:17,566,001	C/T	—	likely benign
rs2123786576	22:17,566,004	C/T	—	uncertain significance
rs752407403	22:17,566,007	C/T	—	uncertain significance
rs577217331	22:17,566,011	T/A	—	conflicting classifications of pathogenicity
rs2123786594	22:17,566,014	C/A	—	likely benign
rs886057200	22:17,566,017	G/T	—	conflicting classifications of pathogenicity
rs1601332814	22:17,566,022	C/G	—	uncertain significance
rs2061321486	22:17,566,034	T/C	—	uncertain significance
rs757752753	22:17,566,035	G/A	—	likely benign
rs1429270259	22:17,566,036	C/T	—	uncertain significance
rs937902710	22:17,566,037	T/G	—	uncertain significance
rs1418150684	22:17,566,038	C/T	—	likely benign
rs539782982	22:17,566,045	C/T	—	uncertain significance
rs41510847	22:17,566,051	G/C	—	uncertain significance
rs1216984686	22:17,566,053	C/T	—	likely benign
rs1297016157	22:17,566,054	G/C	—	uncertain significance
rs896285374	22:17,566,056	G/A	—	likely benign
rs1490955421	22:17,566,061	C/A	—	uncertain significance
rs1222771166	22:17,566,062	C/T	—	likely benign
rs1487756841	22:17,566,064	C/T	—	uncertain significance
rs1188361528	22:17,566,065	G/T	—	likely benign
rs1449112570	22:17,566,074	C/T	—	likely benign
rs1387278734	22:17,566,081	C/A	—	likely benign
rs887188602	22:17,566,086	C/G	—	likely benign
rs2061321959	22:17,566,087	C/G	—	uncertain significance
rs1476573681	22:17,566,101	G/C	—	likely benign
rs1295037189	22:17,566,102	C/G	—	uncertain significance
rs1358015503	22:17,566,107	C/T	—	likely benign
rs1006074686	22:17,566,114	C/A	—	uncertain significance
rs1186749135	22:17,566,119	G/A	—	uncertain significance
rs534287611	22:17,566,131	C/T	—	benign
rs2123786879	22:17,566,135	G/A	—	likely benign
rs1161339186	22:17,566,137	G/C	—	likely benign
rs2270241	22:17,566,206	G/T	—	benign
rs2270242	22:17,566,229	T/A	—	benign
rs12159217	22:17,573,915	G/T	downstream gene variant	—
rs2061370840	22:17,577,934	A/C	—	likely benign
rs369481393	22:17,577,936	C/G	—	likely benign
rs866097972	22:17,577,939	C/G	—	likely benign
rs2123797239	22:17,577,946	C/T	—	likely benign
rs1156352906	22:17,577,953	G/A	—	uncertain significance
rs764531960	22:17,577,955	C/A	—	uncertain significance
rs181987050	22:17,577,957	A/G	—	likely benign
rs143008696	22:17,577,965	C/T	—	conflicting classifications of pathogenicity
rs767860569	22:17,577,966	G/A	—	likely benign
rs538846008	22:17,577,975	T/C	—	uncertain significance
rs2123797291	22:17,577,978	T/C	—	likely pathogenic
rs2517158828	22:17,578,668	G/C	—	likely benign
rs756664595	22:17,578,689	A/G	—	uncertain significance
rs753878546	22:17,578,708	G/A	—	pathogenic
rs1330723939	22:17,578,709	G/A	—	pathogenic
rs1057518745	22:17,578,719	C/T	stop gained	pathogenic
rs886057201	22:17,578,722	A/G	—	uncertain significance
rs2517158932	22:17,578,733	C/G	—	likely benign
rs1389165928	22:17,578,736	C/T	—	likely benign
rs752964419	22:17,578,743	A/G	—	uncertain significance
rs143198423	22:17,578,746	G/A	—	likely benign
rs745774811	22:17,578,750	T/C	—	uncertain significance
rs1568918593	22:17,578,751	G/A	—	likely benign
rs1601340999	22:17,578,766	C/T	—	likely benign
rs2517158978	22:17,578,769	T/C	—	likely benign
rs201996921	22:17,578,770	G/A	—	uncertain significance
rs772083135	22:17,578,773	C/G	—	uncertain significance
rs773666876	22:17,578,774	A/G	—	uncertain significance
rs2517159011	22:17,578,779	C/A	—	uncertain significance
rs553999310	22:17,578,781	A/G	—	likely benign
rs766825875	22:17,578,782	C/A	—	uncertain significance
rs780817422	22:17,578,799	C/T	—	likely benign
rs147495146	22:17,578,800	G/A	—	uncertain significance
rs2517159069	22:17,578,802	G/A	—	likely benign
rs755993710	22:17,578,804	C/T	—	conflicting classifications of pathogenicity
rs749306401	22:17,578,812	G/A	—	uncertain significance
rs2517159112	22:17,578,815	T/C	—	likely pathogenic
rs139951966	22:17,578,820	A/G	—	likely benign
rs201128237	22:17,578,835	T/C	—	likely pathogenic
rs771719685	22:17,578,836	G/A	—	uncertain significance
rs199640693	22:17,578,842	G/T	—	likely benign
rs777115229	22:17,578,853	G/A	—	likely benign
rs41396547	22:17,579,054	T/C	upstream gene variant	—
rs1302696965	22:17,579,645	C/G	—	likely benign
rs371831623	22:17,579,647	C/A	—	likely benign

Showing 100 of 795 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.