rs4819554
This variant is located in the IL17RA gene.
▶Research that mentions this SNP (1)
▶A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patientsAssociationN=200Dina Sabry et al.(2020)· Archives of Dermatological Research
Case-control study of 100 Egyptian psoriasis patients vs 100 controls found rs4819554 (IL-17RA -947A/G) significantly associated with psoriasis susceptibility, with G allele showing OR 2.283 (95% CI 1.321-3.946, p=0.003) and AG genotype OR 3.026 (p=0.007). Serum psoriasin and IL-17 levels were significantly elevated in psoriatic patients.
About IL17RA
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
View all IL17RA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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