IL22
interleukin 22
Summary
This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1182844 | 12:68,641,532 | T/A | downstream gene variant | — |
| rs2227508 | 12:68,641,928 | T/A | downstream gene variant | — |
| rs1220646862 | 12:68,642,589 | G/A | — | uncertain significance |
| rs141353897 | 12:68,642,632 | C/T | — | uncertain significance |
| rs2227507 | 12:68,642,647 | T/C | — | benign |
| rs976748 | 12:68,643,594 | G/T | — | — |
| rs2227503 | 12:68,643,698 | T/C | intron variant | — |
| rs2227501 | 12:68,643,959 | G/T | intron variant | — |
| rs1012356 | 12:68,644,618 | T/A | intron variant | — |
| rs1179251 | 12:68,645,051 | C/G | intron variant | — |
| rs138190698 | 12:68,645,295 | T/C | — | uncertain significance |
| rs2046068 | 12:68,645,975 | T/G | intron variant | — |
| rs2539875786 | 12:68,646,306 | A/T | — | uncertain significance |
| rs760918709 | 12:68,646,322 | G/A | — | likely benign |
| rs1268433293 | 12:68,646,325 | C/T | — | uncertain significance |
| rs770868754 | 12:68,646,418 | G/A | — | uncertain significance |
| rs201118099 | 12:68,646,425 | C/T | — | uncertain significance |
| rs2227491 | 12:68,646,521 | T/C | intron variant | — |
| rs751886272 | 12:68,646,548 | A/G | — | uncertain significance |
| rs994219995 | 12:68,647,082 | C/A | — | uncertain significance |
| rs750997917 | 12:68,647,134 | G/T | — | uncertain significance |
| rs200840384 | 12:68,647,204 | T/G | — | uncertain significance |
| rs2227513 | 12:68,647,339 | T/C | intron variant | — |
| rs2227485 | 12:68,647,713 | G/A | upstream gene variant | — |
| rs2227480 | 12:68,648,342 | G/A | upstream gene variant | — |
| rs2227511 | 12:68,648,356 | C/T | upstream gene variant | — |
| rs2227476 | 12:68,648,816 | A/T | upstream gene variant | — |
| rs2227473 | 12:68,649,038 | C/T | upstream gene variant | — |
| rs2227472 | 12:68,649,133 | T/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.