INCENP

inner centromere protein

Summary

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

Known Variants170 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7921561511:61,895,444A/G——
rs382503511:61,895,476A/G—benign
rs167513011:61,895,541G/A—benign
rs77993774411:61,895,644C/T—uncertain significance
rs92750740911:61,895,649C/T—uncertain significance
rs145797848211:61,895,670G/A—uncertain significance
rs91771127611:61,895,718A/G—uncertain significance
rs167513111:61,895,741G/A—benign
rs126039610711:61,895,754G/T—uncertain significance
rs74818708211:61,895,761G/A—uncertain significance
rs179294611:61,896,215G/A—benign
rs194381398811:61,896,259C/T—uncertain significance
rs194381449011:61,896,277C/T—uncertain significance
rs77253990611:61,896,295G/A—uncertain significance
rs167513211:61,896,589T/G—benign
rs6189366111:61,897,073T/C—benign
rs179294411:61,897,197C/T—benign
rs76944544211:61,897,254G/T—uncertain significance
rs13905419311:61,897,273C/T—uncertain significance
rs36974263411:61,897,274G/A—uncertain significance
rs37339870311:61,897,286T/C—uncertain significance
rs20041666111:61,897,292C/T—uncertain significance
rs14646522511:61,897,295G/A—uncertain significance
rs1228150311:61,897,298G/A—benign
rs102788564611:61,897,326G/T—uncertain significance
rs167513311:61,897,359T/C—benign
rs77209469311:61,897,376G/A—uncertain significance
rs77325430611:61,897,382C/T—uncertain significance
rs14703384811:61,897,396G/A—uncertain significance
rs11221833611:61,897,404T/C—benign
rs3444155911:61,897,409C/T—benign
rs254153223711:61,897,415C/T—uncertain significance
rs3421012511:61,897,468G/A—benign
rs53361317911:61,897,495G/T—uncertain significance
rs77764158311:61,897,526G/A—uncertain significance
rs20209381011:61,897,567G/A—uncertain significance
rs14323599711:61,897,618A/G—likely benign
rs76385783811:61,897,621T/C—uncertain significance
rs56509005411:61,897,634C/Tmissense variant—
rs76258000111:61,897,715C/T—uncertain significance
rs13991407411:61,897,739G/T—uncertain significance
rs14982098611:61,897,753C/T—uncertain significance
rs254153498211:61,897,811C/G—likely benign
rs19973431611:61,897,838G/A—uncertain significance
rs14832073511:61,897,840G/T—uncertain significance
rs254153526411:61,897,873A/G—uncertain significance
rs130068052611:61,897,875G/A—likely benign
rs53891440411:61,897,907T/G—uncertain significance
rs78033258111:61,897,924G/A—uncertain significance
rs74654328411:61,897,937C/T—likely benign
rs14451455311:61,897,948G/A—uncertain significance
rs77942713811:61,898,021A/G—uncertain significance
rs54397511511:61,898,044G/C—uncertain significance
rs7474434911:61,898,174C/T—benign
rs179294311:61,898,192G/A—benign
rs56449756811:61,903,766A/G——
rs11695649411:61,905,129C/Tintron variant—
rs254155351711:61,905,299C/G—uncertain significance
rs57470661711:61,905,351G/T—uncertain significance
rs1227171411:61,905,985G/A—benign
rs6175122611:61,906,216G/A—benign
rs118429085511:61,906,223T/G—uncertain significance
rs161406011:61,906,299A/G—benign
rs167512611:61,906,374T/Csynonymous variantbenign
rs19982977511:61,906,403C/T—uncertain significance
rs254155771411:61,906,411G/A—uncertain significance
rs1123092211:61,906,538G/A—benign
rs374124611:61,907,631T/A—benign
rs14411786511:61,907,716G/A—benign
rs6189367911:61,907,821C/A—benign
rs167512411:61,907,909G/A—benign
rs1279561111:61,907,969C/T—benign
rs6189368011:61,908,022G/A—benign
rs76432153711:61,908,177A/G—uncertain significance
rs14157712111:61,908,184G/A—uncertain significance
rs74567776811:61,908,219G/C—uncertain significance
rs13798462911:61,908,267C/G—uncertain significance
rs77720700211:61,908,280G/T—uncertain significance
rs76984477311:61,908,400C/T—uncertain significance
rs120918711911:61,908,409C/G—uncertain significance
rs227728311:61,908,440C/T—benign
rs14479738611:61,908,441G/A—uncertain significance
rs76616123011:61,908,466G/A—uncertain significance
rs7349925011:61,908,524T/G—benign
rs167512311:61,908,672A/G—benign
rs5913953111:61,912,210C/T—benign
rs89838211:61,912,400G/A—benign
rs14011227911:61,912,463C/T—uncertain significance
rs20135728811:61,912,464G/A—uncertain significance
rs133885447111:61,912,518A/T—uncertain significance
rs99736314111:61,912,538C/T—uncertain significance
rs194421446611:61,912,657C/G—uncertain significance
rs76890748511:61,912,673A/G—uncertain significance
rs130460872011:61,912,708A/C—uncertain significance
rs19978519911:61,912,753A/G—uncertain significance
rs179292511:61,913,079C/T—benign
rs7776528411:61,913,091G/C—benign
rs37775992011:61,913,113C/T—uncertain significance
rs11646274211:61,913,144C/T—benign
rs14050544011:61,913,177G/A—uncertain significance

Showing 100 of 170 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.