ING5
inhibitor of growth family member 5
Summary
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs34174712 | 2:242,631,579 | T/A | — | — |
| rs34426467 | 2:242,634,122 | T/G | — | — |
| rs7586855 | 2:242,636,359 | T/C | downstream gene variant | — |
| rs4675894 | 2:242,638,453 | T/A | — | — |
| rs946862250 | 2:242,641,488 | C/T | — | uncertain significance |
| rs979210386 | 2:242,641,493 | A/C | — | uncertain significance |
| rs35736498 | 2:242,644,728 | C/T | intron variant | — |
| rs376724030 | 2:242,648,702 | C/T | — | uncertain significance |
| rs1285779080 | 2:242,648,703 | G/A | — | uncertain significance |
| rs778176408 | 2:242,648,705 | G/A | — | uncertain significance |
| rs146454591 | 2:242,648,761 | C/T | — | benign |
| rs200232942 | 2:242,648,773 | G/T | — | uncertain significance |
| rs754232441 | 2:242,650,895 | G/T | — | uncertain significance |
| rs77687125 | 2:242,652,848 | C/G | — | — |
| rs62191350 | 2:242,653,298 | G/T | — | — |
| rs369577212 | 2:242,662,382 | G/A | — | uncertain significance |
| rs2549772577 | 2:242,662,664 | A/T | — | uncertain significance |
| rs749411402 | 2:242,664,441 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.