INO80

INO80 complex ATPase subunit

Summary

This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Known Variants107 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs775509728	15:41,272,488	C/A	—	uncertain significance
rs577749000	15:41,272,491	G/A	—	likely benign
rs763157145	15:41,272,515	C/T	—	uncertain significance
rs763562840	15:41,272,538	C/G	—	uncertain significance
rs145802648	15:41,272,561	A/T	—	uncertain significance
rs1893777818	15:41,272,591	C/T	—	uncertain significance
rs2542611211	15:41,272,597	G/C	—	uncertain significance
rs760222077	15:41,272,599	C/T	—	uncertain significance
rs7173954	15:41,275,014	G/T	—	benign
rs753014093	15:41,275,084	C/T	—	uncertain significance
rs548072003	15:41,275,130	T/C	—	likely benign
rs761866608	15:41,275,170	C/T	—	uncertain significance
rs1450414884	15:41,275,219	C/G	—	uncertain significance
rs1893891672	15:41,275,222	G/A	—	uncertain significance
rs1455415165	15:41,275,235	G/C	—	uncertain significance
rs1566897746	15:41,275,258	T/C	—	uncertain significance
rs139570772	15:41,275,979	G/A	—	likely benign
rs149995664	15:41,276,035	C/G	—	uncertain significance
rs11855248	15:41,276,158	G/A	—	benign
rs1893939420	15:41,276,454	C/G	—	uncertain significance
rs760118016	15:41,276,462	T/C	—	uncertain significance
rs142469845	15:41,276,477	G/A	—	likely benign
rs151317571	15:41,276,492	A/G	—	uncertain significance
rs903187266	15:41,276,505	C/T	—	likely benign
rs374492938	15:41,276,508	C/T	—	uncertain significance
rs61757083	15:41,277,551	T/C	—	benign
rs767777234	15:41,277,555	C/T	—	uncertain significance
rs759343873	15:41,277,601	G/C	—	uncertain significance
rs141223506	15:41,277,615	C/T	—	conflicting classifications of pathogenicity
rs12438816	15:41,277,733	T/G	—	benign
rs751810203	15:41,279,306	T/C	—	uncertain significance
rs199722402	15:41,279,384	C/T	missense variant	pathogenic
rs12905926	15:41,283,408	G/A	intron variant	—
rs71403578	15:41,295,532	C/T	—	—
rs376233588	15:41,297,826	C/T	—	likely benign
rs2542681992	15:41,297,853	C/T	—	uncertain significance
rs368400854	15:41,305,271	T/C	coding sequence variant	—
rs2044205817	15:41,308,362	A/C	—	uncertain significance
rs34178030	15:41,308,365	A/C	—	likely benign
rs3214068	15:41,313,064	C/G	—	benign
rs1046127032	15:41,313,101	G/C	—	uncertain significance
rs752657091	15:41,313,167	A/G	—	uncertain significance
rs1448541991	15:41,313,287	G/C	—	uncertain significance
rs745717114	15:41,319,804	G/C	—	uncertain significance
rs2542758104	15:41,319,815	A/G	—	likely benign
rs201049180	15:41,319,835	G/A	—	uncertain significance
rs149600837	15:41,319,844	G/A	—	uncertain significance
rs763793662	15:41,319,852	G/A	—	uncertain significance
rs758299239	15:41,319,884	C/G	—	uncertain significance
rs61757230	15:41,337,180	G/A	—	benign
rs115089447	15:41,337,196	T/C	—	benign
rs76113356	15:41,337,225	C/T	—	likely benign
rs753511359	15:41,339,625	G/C	—	uncertain significance
rs747338599	15:41,339,655	T/C	—	likely benign
rs34153025	15:41,339,697	T/C	—	likely benign
rs368326435	15:41,340,446	G/T	—	uncertain significance
rs763268099	15:41,340,464	C/A	—	uncertain significance
rs1233776320	15:41,340,465	C/A	—	uncertain significance
rs192836335	15:41,340,491	T/A	—	benign
rs777984557	15:41,341,486	T/A	—	uncertain significance
rs775445730	15:41,341,489	C/G	—	uncertain significance
rs544721777	15:41,341,506	A/G	—	uncertain significance
rs2542833444	15:41,341,516	G/T	—	uncertain significance
rs140394841	15:41,341,532	A/C	—	uncertain significance
rs2899010	15:41,346,092	T/C	—	benign
rs753920827	15:41,347,470	G/A	—	likely benign
rs2306083	15:41,347,658	G/A	—	benign
rs111767851	15:41,348,808	A/T	—	likely benign
rs748202532	15:41,348,853	T/C	—	likely benign
rs147454171	15:41,352,074	G/A	—	uncertain significance
rs2542889272	15:41,361,826	G/A	—	uncertain significance
rs2045292312	15:41,362,669	G/C	—	uncertain significance
rs730882226	15:41,364,151	A/G	missense variant	pathogenic
rs755068070	15:41,364,207	C/T	—	uncertain significance
rs201642978	15:41,364,208	G/A	—	uncertain significance
rs771890200	15:41,364,234	G/C	—	uncertain significance
rs765141721	15:41,364,264	G/T	—	likely benign
rs538656200	15:41,365,627	C/T	—	uncertain significance
rs1403460523	15:41,365,630	G/C	—	uncertain significance
rs1342712835	15:41,365,657	G/A	—	uncertain significance
rs1398581277	15:41,366,612	T/C	—	uncertain significance
rs144817447	15:41,368,202	T/C	intron variant	—
rs759978928	15:41,372,035	G/T	—	uncertain significance
rs775876676	15:41,372,045	A/C	—	uncertain significance
rs34467689	15:41,372,055	G/T	—	benign
rs780868252	15:41,372,096	G/A	—	uncertain significance
rs186749333	15:41,377,607	C/T	—	uncertain significance
rs866583951	15:41,377,614	G/C	—	uncertain significance
rs1484630242	15:41,377,666	T/C	—	likely benign
rs760716004	15:41,377,700	T/A	—	uncertain significance
rs575756145	15:41,377,715	C/T	—	uncertain significance
rs758135552	15:41,379,792	T/C	—	uncertain significance
rs145473172	15:41,384,310	T/C	—	benign
rs75953315	15:41,384,330	G/A	—	benign
rs374813039	15:41,384,354	G/A	—	benign
rs778979367	15:41,384,363	A/G	—	likely benign
rs691830	15:41,387,312	A/G	intron variant	—
rs780788447	15:41,387,965	A/C	—	uncertain significance
rs149372207	15:41,387,969	C/T	—	uncertain significance
rs758419929	15:41,387,980	G/A	—	uncertain significance

Showing 100 of 107 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.