INTS12

integrator complex subunit 12

Summary

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Known Variants22 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3769920024:106,603,942T/Cuncertain significance
rs13621026584:106,604,048C/Tuncertain significance
rs1451748074:106,604,070C/Tlikely benign
rs7561990764:106,604,096G/Cuncertain significance
rs7494764344:106,604,101A/Guncertain significance
rs7757995214:106,604,137T/Cuncertain significance
rs7746406154:106,604,474T/Cuncertain significance
rs24765410304:106,607,854C/Tuncertain significance
rs3682436894:106,607,973G/Auncertain significance
rs1393554474:106,613,227C/Tlikely benign
rs11693919044:106,614,576T/Clikely benign
rs5311874564:106,614,643T/Auncertain significance
rs1472739384:106,616,677T/Auncertain significance
rs7780818264:106,616,708C/Auncertain significance
rs13510151384:106,616,767T/Cuncertain significance
rs17318342774:106,616,774C/Tuncertain significance
rs17318362694:106,616,806A/Guncertain significance
rs1120373094:106,617,136G/Aintron variant
rs117271894:106,619,140G/Tintron variant
rs7706121724:106,621,020C/Tuncertain significance
rs24765845684:106,621,051A/Guncertain significance
rs1484933964:106,621,128A/Guncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.