rs11727189
This is a intron variant variant in the INTS12 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
pulmonary function measurement, forced expiratory volume
Hancock DB et al. “Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.” Nature Genetics 42(1):45-52 (2010)
Allele T
OR 64.70
p 5.0e-17
N 20,890
Large GWAS
European
About INTS12
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
View all INTS12 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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