IQGAP3

IQ motif containing GTPase activating protein 3

Summary

Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants148 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs140982853	1:156,496,285	C/T	—	uncertain significance
rs754377033	1:156,496,298	T/C	—	uncertain significance
rs2525593546	1:156,496,318	A/G	—	uncertain significance
rs2525593896	1:156,496,333	T/A	—	uncertain significance
rs2525594549	1:156,496,339	T/A	—	uncertain significance
rs202051702	1:156,497,764	G/A	—	uncertain significance
rs1436743385	1:156,497,770	T/C	—	uncertain significance
rs148884446	1:156,497,823	G/A	—	uncertain significance
rs561559322	1:156,497,826	G/A	—	uncertain significance
rs150194624	1:156,498,307	G/T	—	uncertain significance
rs770932490	1:156,498,308	C/G	—	uncertain significance
rs1674222106	1:156,498,330	C/G	—	uncertain significance
rs201066805	1:156,498,716	G/A	—	likely benign
rs772944929	1:156,498,742	G/A	—	uncertain significance
rs762945955	1:156,498,744	A/G	—	uncertain significance
rs2525617632	1:156,498,765	C/T	—	uncertain significance
rs374572830	1:156,498,768	T/A	—	uncertain significance
rs375639213	1:156,498,777	T/C	—	uncertain significance
rs1557914785	1:156,498,808	A/C	—	uncertain significance
rs748938834	1:156,498,868	G/A	—	uncertain significance
rs775521236	1:156,498,880	G/A	—	uncertain significance
rs756649345	1:156,499,908	C/T	—	uncertain significance
rs778568841	1:156,499,918	C/T	—	likely benign
rs374687381	1:156,499,937	G/T	—	uncertain significance
rs368191209	1:156,499,938	C/T	—	uncertain significance
rs774732936	1:156,499,964	C/T	—	likely benign
rs149623112	1:156,499,967	C/T	—	uncertain significance
rs750097388	1:156,499,983	C/T	—	uncertain significance
rs374144760	1:156,499,989	G/A	—	uncertain significance
rs769722333	1:156,500,007	G/A	—	uncertain significance
rs772234683	1:156,500,018	T/G	—	uncertain significance
rs201070239	1:156,500,033	C/T	—	likely benign
rs369608391	1:156,500,053	C/T	—	likely benign
rs756180940	1:156,500,054	G/A	—	uncertain significance
rs1044754353	1:156,500,072	G/A	—	uncertain significance
rs747056561	1:156,500,078	C/T	—	uncertain significance
rs768730139	1:156,500,081	C/T	—	uncertain significance
rs115742679	1:156,500,096	T/C	—	likely benign
rs201700249	1:156,501,021	G/A	—	benign
rs559588528	1:156,502,821	C/T	—	uncertain significance
rs757666735	1:156,502,840	C/T	—	likely benign
rs4661044	1:156,502,870	C/T	—	benign
rs1442306955	1:156,502,880	T/A	—	uncertain significance
rs200172264	1:156,502,887	C/T	—	uncertain significance
rs139057334	1:156,502,888	G/A	—	likely benign
rs41267377	1:156,503,560	C/T	—	benign
rs368946935	1:156,503,576	G/C	—	uncertain significance
rs2525656531	1:156,503,618	A/G	—	uncertain significance
rs141890307	1:156,503,635	A/G	—	likely benign
rs1243252196	1:156,503,652	G/T	—	uncertain significance
rs1338961852	1:156,503,663	A/G	—	uncertain significance
rs777426497	1:156,503,793	C/A	—	likely benign
rs80078241	1:156,503,828	G/A	—	likely benign
rs774351199	1:156,503,838	A/C	—	uncertain significance
rs34620734	1:156,503,876	G/A	—	likely benign
rs1674566970	1:156,503,927	G/T	—	uncertain significance
rs1026638311	1:156,504,303	G/A	—	uncertain significance
rs745895086	1:156,504,335	C/A	—	uncertain significance
rs61740414	1:156,504,370	A/G	—	benign
rs769106341	1:156,504,425	G/C	—	uncertain significance
rs777139627	1:156,504,426	C/T	—	likely benign
rs1202540492	1:156,504,456	C/T	—	uncertain significance
rs752573298	1:156,504,469	G/A	—	likely benign
rs780278881	1:156,504,500	C/T	—	uncertain significance
rs778363628	1:156,504,950	C/T	—	likely benign
rs776558515	1:156,504,979	G/A	—	likely benign
rs924703927	1:156,505,025	T/G	—	uncertain significance
rs1391470130	1:156,505,026	A/G	—	uncertain significance
rs1571320137	1:156,506,967	A/T	—	likely pathogenic
rs1466453496	1:156,506,988	G/A	—	uncertain significance
rs34980426	1:156,507,025	C/T	—	benign
rs769667331	1:156,507,036	C/A	—	uncertain significance
rs771409196	1:156,508,708	C/G	—	uncertain significance
rs141646662	1:156,508,742	C/T	—	uncertain significance
rs150506468	1:156,508,743	G/A	—	uncertain significance
rs1674850371	1:156,508,802	T/G	—	uncertain significance
rs751536368	1:156,509,220	C/T	—	uncertain significance
rs111494634	1:156,509,223	C/T	—	uncertain significance
rs931645588	1:156,509,315	G/A	—	likely benign
rs1674893832	1:156,509,705	C/G	—	uncertain significance
rs754197779	1:156,510,513	C/T	—	uncertain significance
rs754484431	1:156,510,675	C/T	—	uncertain significance
rs751001051	1:156,510,676	G/T	—	uncertain significance
rs1674947810	1:156,510,705	T/C	—	uncertain significance
rs115910925	1:156,511,801	A/C	intron variant	—
rs770264698	1:156,513,836	A/C	—	uncertain significance
rs201097448	1:156,513,961	G/A	—	uncertain significance
rs147371313	1:156,513,984	C/T	—	uncertain significance
rs564840911	1:156,514,246	T/C	—	uncertain significance
rs139482694	1:156,517,904	G/A	—	likely benign
rs146588513	1:156,517,927	G/C	—	uncertain significance
rs768155797	1:156,517,945	G/A	—	uncertain significance
rs1257476693	1:156,518,156	G/T	—	uncertain significance
rs1557932848	1:156,518,219	A/G	—	uncertain significance
rs775665101	1:156,518,262	C/T	—	uncertain significance
rs11264496	1:156,518,433	C/T	—	benign
rs1316181406	1:156,518,447	C/T	—	uncertain significance
rs370974075	1:156,518,477	C/T	—	uncertain significance
rs59573847	1:156,520,100	C/A	—	benign
rs79245953	1:156,520,526	C/T	intron variant	—

Showing 100 of 148 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.