rs41267377

This variant is located in the IQGAP3 gene.

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ClinVar annotation

Benign
2 submitters

IQGAP3-related disorder; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Familial pancreatic carcinoma; Colon adenocarcinoma; Ovarian cancer; Colorectal cancer; Gastric cancer; Nonpapillary renal cell carcinoma; Lung cancer; Uterine carcinosarcoma; Thymoma; Cholangiocarcinoma; Acute myeloid leukemia; Sarcoma; Ovarian serous cystadenocarcinoma; Malignant tumor of esophagus; Adrenocortical carcinoma, hereditary; Cervical cancer

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About IQGAP3

Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Apr 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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