IRAK1

interleukin 1 receptor associated kinase 1

Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants62 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3027898X:153,275,890C/G
rs375975243X:153,277,362C/Tuncertain significance
rs2239673X:153,277,889C/Tbenign
rs149773870X:153,277,986G/Cuncertain significance
rs147444875X:153,277,988G/Auncertain significance
rs782722759X:153,278,057T/Cuncertain significance
rs145414165X:153,278,500C/Tuncertain significance
rs35638718X:153,278,550G/Abenign
rs34112487X:153,278,569C/Tlikely benign
rs1557127993X:153,278,601C/Auncertain significance
rs782780153X:153,278,625C/Tbenign
rs199501854X:153,278,626G/Auncertain significance
rs3027905X:153,278,723T/Clikely benign
rs782687454X:153,278,743A/Guncertain significance
rs782284654X:153,278,752C/Tuncertain significance
rs140583367X:153,278,782C/Tlikely benign
rs782393640X:153,278,783G/Alikely benign
rs1059703X:153,278,829G/Amissense variantbenign
rs368063747X:153,278,836C/Tuncertain significance
rs782357859X:153,279,560A/Guncertain significance
rs2521924158X:153,279,569T/Cuncertain significance
rs2065722135X:153,279,572G/Cuncertain significance
rs2065722170X:153,279,573G/Cuncertain significance
rs782315247X:153,279,615T/Auncertain significance
rs782373597X:153,279,624C/Tuncertain significance
rs2065723451X:153,279,731T/Cuncertain significance
rs5945174X:153,279,858G/C
rs2521931038X:153,281,491T/Cuncertain significance
rs782768715X:153,281,508G/Alikely benign
rs1229790473X:153,281,929C/Guncertain significance
rs782053956X:153,281,984C/Tlikely benign
rs2521933469X:153,281,986G/Auncertain significance
rs202203227X:153,281,996G/Alikely benign
rs11556424X:153,282,020G/Abenign
rs149520139X:153,282,026G/Alikely benign
rs143993525X:153,282,028G/Alikely benign
rs2065752119X:153,283,448T/Clikely benign
rs1194250023X:153,283,462A/Tuncertain significance
rs781836564X:153,283,522C/Tuncertain significance
rs1557130061X:153,283,744G/Tlikely benign
rs368268634X:153,284,040C/Tlikely benign
rs782263874X:153,284,053C/Tlikely benign
rs782106693X:153,284,140C/Tlikely benign
rs2521943549X:153,284,151G/Auncertain significance
rs10127175X:153,284,172A/Tbenign
rs1059702X:153,284,192A/Gmissense variantbenign
rs11465830X:153,284,198C/Tbenign
rs782216618X:153,284,428T/Guncertain significance
rs202066173X:153,284,436G/Aconflicting classifications of pathogenicity
rs2521945482X:153,284,442G/Tuncertain significance
rs782295969X:153,284,472G/Auncertain significance
rs1059701X:153,284,483G/Abenign
rs782338967X:153,284,490C/Tuncertain significance
rs782422452X:153,284,511G/Cuncertain significance
rs994323796X:153,284,663T/Guncertain significance
rs2148643448X:153,284,689G/Auncertain significance
rs2521947003X:153,284,694C/Guncertain significance
rs201911518X:153,284,723T/Gbenign
rs11465829X:153,284,746G/Abenign
rs200423500X:153,284,759G/Auncertain significance
rs782636633X:153,285,057G/Tlikely benign
rs2065769801X:153,285,238T/Guncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.