JAM2

junctional adhesion molecule 2

Summary

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

Known Variants43 total

rsidPosition (GRCh37)AllelesClassClinVar
rs14550462621:27,011,458T/Abenign
rs11811556921:27,012,088C/Abenign
rs160097844121:27,012,134A/Gpathogenic
rs813263921:27,012,154C/Abenign
rs147367331421:27,012,198G/Auncertain significance
rs282984121:27,023,022C/Tintron variant
rs2850721921:27,047,662A/T
rs282986321:27,056,099A/Cbenign
rs75440247321:27,056,246C/Tuncertain significance
rs813360221:27,056,250A/Gbenign
rs282986621:27,059,071T/Aintron variant
rs998426021:27,065,860T/Cbenign
rs6114067821:27,065,919A/Gbenign
rs251679121921:27,066,089A/Cuncertain significance
rs138364130921:27,066,149G/Apathogenic
rs998275021:27,071,005A/Gbenign
rs20096228521:27,071,018C/Auncertain significance
rs76718871221:27,071,069G/Cuncertain significance
rs123094117921:27,071,098G/Cpathogenic
rs212339904321:27,071,112T/Cuncertain significance
rs78021740921:27,071,115G/Auncertain significance
rs251680214021:27,074,490T/Clikely benign
rs75360453221:27,074,534G/Auncertain significance
rs251680225521:27,074,536A/Guncertain significance
rs78126191821:27,074,569C/Tpathogenic
rs14588137621:27,074,574G/Cuncertain significance
rs7333596521:27,074,708C/Tbenign
rs227622021:27,078,270G/Abenign
rs727791721:27,078,296C/Tuncertain significance
rs20021866321:27,078,323G/Auncertain significance
rs251680654821:27,078,324T/Cuncertain significance
rs37018772021:27,078,350G/Auncertain significance
rs37100915921:27,078,362G/Auncertain significance
rs282987021:27,078,428T/Abenign
rs202622421:27,078,633G/Abenign
rs5625648221:27,081,725T/Gbenign
rs727612921:27,081,942A/Gbenign
rs251681383321:27,084,653A/Guncertain significance
rs997638221:27,084,686A/Cbenign
rs813448721:27,086,850C/Tbenign
rs813451321:27,086,916C/Abenign
rs282987721:27,087,044T/Cbenign
rs282987821:27,087,165C/Tbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.