KCTD13
potassium channel tetramerization domain containing 13
Summary
Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs753862246 | 16:29,918,272 | C/T | — | uncertain significance |
| rs2068625903 | 16:29,918,368 | G/A | — | uncertain significance |
| rs143894366 | 16:29,922,371 | G/A | — | likely benign |
| rs2543495775 | 16:29,922,461 | C/G | — | uncertain significance |
| rs545229461 | 16:29,933,198 | A/G | coding sequence variant | — |
| rs1263689660 | 16:29,934,532 | C/A | — | uncertain significance |
| rs1275779123 | 16:29,934,539 | A/C | — | uncertain significance |
| rs768347611 | 16:29,934,547 | C/T | — | likely benign |
| rs542780651 | 16:29,934,593 | G/A | — | uncertain significance |
| rs750161117 | 16:29,934,632 | T/C | — | uncertain significance |
| rs750687011 | 16:29,934,636 | G/A | — | uncertain significance |
| rs747715908 | 16:29,934,657 | C/T | — | uncertain significance |
| rs11644809 | 16:29,935,505 | G/C | — | — |
| rs142314307 | 16:29,937,150 | T/G | — | uncertain significance |
| rs2543527469 | 16:29,937,280 | C/G | — | uncertain significance |
| rs748493723 | 16:29,937,282 | C/G | — | uncertain significance |
| rs774583685 | 16:29,937,306 | C/T | — | uncertain significance |
| rs200844395 | 16:29,937,358 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.