rs545229461

This is a coding sequence variant variant in the KCTD13 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

triacylglycerol 50:2 measurement

Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)

Allele G

OR 1.66

p 3.0e-9

N 4,492

Large GWAS

European

glycerophospholipid measurement

Allele G

OR 1.55

p 3.0e-8

N 4,492

Large GWAS

European

About KCTD13

Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

View all KCTD13 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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