KDM3B
lysine demethylase 3B
Summary
Predicted to enable chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of acute lymphoblastic leukemia; breast cancer; colorectal cancer; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants230 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200772506 | 5:137,688,497 | G/A | — | benign |
| rs2480105670 | 5:137,688,516 | A/G | — | uncertain significance |
| rs1344459131 | 5:137,688,546 | C/G | — | uncertain significance |
| rs942700667 | 5:137,688,576 | C/T | — | uncertain significance |
| rs1761362629 | 5:137,688,581 | G/C | — | uncertain significance |
| rs1029580499 | 5:137,688,588 | G/A | — | uncertain significance |
| rs1233610442 | 5:137,688,590 | G/A | — | uncertain significance |
| rs746544536 | 5:137,688,611 | C/T | — | likely benign |
| rs377463473 | 5:137,688,617 | C/T | — | pathogenic |
| rs1390295003 | 5:137,688,620 | G/T | — | uncertain significance |
| rs2480106235 | 5:137,688,625 | G/T | — | uncertain significance |
| rs4835677 | 5:137,700,251 | A/T | intron variant | — |
| rs78702109 | 5:137,705,715 | G/A | intron variant | — |
| rs757647 | 5:137,707,315 | G/C | — | — |
| rs4835678 | 5:137,708,434 | C/T | — | benign |
| rs2126922709 | 5:137,708,435 | G/A | — | uncertain significance |
| rs1761904420 | 5:137,708,447 | G/T | — | pathogenic |
| rs2126922767 | 5:137,708,481 | C/T | — | uncertain significance |
| rs2126922810 | 5:137,708,501 | C/T | — | pathogenic |
| rs2480156742 | 5:137,710,782 | A/G | — | uncertain significance |
| rs1761964120 | 5:137,710,789 | C/T | — | uncertain significance |
| rs1761965198 | 5:137,710,844 | G/A | — | uncertain significance |
| rs201211181 | 5:137,710,848 | C/T | — | likely pathogenic |
| rs753246528 | 5:137,710,858 | G/A | — | likely benign |
| rs1761966500 | 5:137,710,896 | G/C | — | uncertain significance |
| rs10043984 | 5:137,712,121 | C/T | intron variant | — |
| rs142142267 | 5:137,713,420 | T/G | — | uncertain significance |
| rs2126929363 | 5:137,713,429 | C/A | — | uncertain significance |
| rs2480165345 | 5:137,713,442 | G/C | — | uncertain significance |
| rs1303337780 | 5:137,713,443 | A/G | — | uncertain significance |
| rs758484771 | 5:137,713,512 | G/A | — | uncertain significance |
| rs1246498637 | 5:137,713,521 | A/G | — | likely benign |
| rs759055511 | 5:137,713,522 | C/T | — | likely benign |
| rs1255839456 | 5:137,715,275 | C/A | — | uncertain significance |
| rs55729115 | 5:137,715,367 | C/T | — | likely benign |
| rs755231178 | 5:137,715,372 | G/A | — | uncertain significance |
| rs752857714 | 5:137,715,385 | G/A | — | likely benign |
| rs10073922 | 5:137,717,213 | G/A | — | benign |
| rs2480175707 | 5:137,717,226 | G/C | — | uncertain significance |
| rs2126935013 | 5:137,717,233 | G/T | — | uncertain significance |
| rs6865472 | 5:137,717,265 | G/A | — | benign |
| rs1472359044 | 5:137,721,711 | G/T | — | uncertain significance |
| rs576887795 | 5:137,721,734 | A/G | — | likely benign |
| rs148391987 | 5:137,721,740 | C/T | — | likely benign |
| rs746368708 | 5:137,721,766 | T/C | — | likely benign |
| rs1762253291 | 5:137,721,777 | G/C | — | uncertain significance |
| rs1422937724 | 5:137,721,783 | C/T | — | uncertain significance |
| rs2480189341 | 5:137,721,810 | G/C | — | uncertain significance |
| rs145133800 | 5:137,721,873 | G/C | — | uncertain significance |
| rs868682027 | 5:137,721,880 | G/T | — | uncertain significance |
| rs778725552 | 5:137,721,892 | G/T | — | uncertain significance |
| rs1762257015 | 5:137,721,937 | A/G | — | pathogenic |
| rs140546320 | 5:137,721,958 | C/T | — | likely benign |
| rs2480189985 | 5:137,721,981 | A/C | — | uncertain significance |
| rs200556196 | 5:137,721,990 | A/G | — | likely benign |
| rs2480190184 | 5:137,722,017 | A/C | — | uncertain significance |
| rs144389568 | 5:137,722,064 | A/T | — | likely benign |
| rs772313729 | 5:137,722,077 | A/C | — | likely benign |
| rs201414691 | 5:137,722,107 | C/T | — | likely benign |
| rs2480190622 | 5:137,722,119 | G/A | — | uncertain significance |
| rs751167517 | 5:137,722,134 | G/A | — | uncertain significance |
| rs2480190755 | 5:137,722,146 | G/A | — | uncertain significance |
| rs374815700 | 5:137,722,155 | A/C | — | likely benign |
| rs748515665 | 5:137,722,161 | G/C | — | uncertain significance |
| rs368600560 | 5:137,722,165 | A/T | — | uncertain significance |
| rs777912581 | 5:137,722,189 | C/G | — | uncertain significance |
| rs1211444657 | 5:137,722,229 | A/T | — | uncertain significance |
| rs200210901 | 5:137,722,242 | G/A | — | likely benign |
| rs184734460 | 5:137,722,246 | C/G | — | benign |
| rs1580902363 | 5:137,722,272 | G/C | — | likely benign |
| rs2480191638 | 5:137,722,300 | C/G | — | uncertain significance |
| rs199770910 | 5:137,722,301 | C/T | — | likely benign |
| rs370533044 | 5:137,722,303 | C/T | — | conflicting classifications of pathogenicity |
| rs6859449 | 5:137,723,582 | A/G | — | — |
| rs56336506 | 5:137,725,469 | C/G | intron variant | — |
| rs757500707 | 5:137,726,750 | C/T | — | likely benign |
| rs145200810 | 5:137,726,758 | A/G | — | likely benign |
| rs2480206487 | 5:137,726,796 | C/G | — | uncertain significance |
| rs374421164 | 5:137,726,799 | A/G | — | likely benign |
| rs141171612 | 5:137,726,815 | A/C | — | likely benign |
| rs762297293 | 5:137,726,828 | T/C | — | likely benign |
| rs1227387918 | 5:137,726,846 | T/A | — | uncertain significance |
| rs181005843 | 5:137,726,857 | A/G | — | likely benign |
| rs1762418047 | 5:137,726,913 | C/T | — | uncertain significance |
| rs200501442 | 5:137,726,943 | C/G | — | likely benign |
| rs2480207512 | 5:137,726,964 | C/G | — | uncertain significance |
| rs2480207544 | 5:137,726,973 | C/A | — | uncertain significance |
| rs145081457 | 5:137,727,000 | G/A | — | likely benign |
| rs898304009 | 5:137,727,016 | C/G | — | uncertain significance |
| rs138862008 | 5:137,727,041 | G/A | — | conflicting classifications of pathogenicity |
| rs374559198 | 5:137,727,093 | G/A | — | uncertain significance |
| rs2480208447 | 5:137,727,111 | C/G | — | uncertain significance |
| rs543390273 | 5:137,727,140 | C/T | — | uncertain significance |
| rs151196317 | 5:137,727,141 | G/A | — | uncertain significance |
| rs759653444 | 5:137,727,159 | G/A | — | conflicting classifications of pathogenicity |
| rs34608821 | 5:137,727,169 | G/T | — | likely benign |
| rs1211766842 | 5:137,727,182 | C/A | — | uncertain significance |
| rs2480209254 | 5:137,727,198 | C/T | — | uncertain significance |
| rs1457414355 | 5:137,727,312 | C/T | — | uncertain significance |
| rs375025015 | 5:137,727,335 | C/G | — | uncertain significance |
Showing 100 of 230 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.