KIF27

kinesin family member 27

Summary

This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

Known Variants102 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs140974886	9:86,451,944	G/T	—	uncertain significance
rs1945939519	9:86,452,001	C/T	—	uncertain significance
rs761977367	9:86,452,043	C/T	—	uncertain significance
rs904928731	9:86,452,070	T/A	—	uncertain significance
rs2537961225	9:86,452,088	C/T	—	uncertain significance
rs1390436829	9:86,452,106	G/C	—	uncertain significance
rs747561292	9:86,452,130	G/A	—	uncertain significance
rs2537963486	9:86,452,139	T/C	—	uncertain significance
rs764086639	9:86,452,191	G/C	—	uncertain significance
rs561598508	9:86,452,224	G/A	—	uncertain significance
rs140117578	9:86,452,226	A/G	—	uncertain significance
rs748179128	9:86,452,259	G/A	—	uncertain significance
rs2537968638	9:86,452,296	C/G	—	uncertain significance
rs756676470	9:86,457,242	A/G	—	uncertain significance
rs762873465	9:86,457,289	G/C	—	uncertain significance
rs1400392636	9:86,457,302	C/A	—	uncertain significance
rs142648961	9:86,463,006	A/C	intron variant	—
rs143020014	9:86,463,210	G/A	—	—
rs1384078903	9:86,465,107	G/C	—	uncertain significance
rs775056643	9:86,465,116	C/G	—	uncertain significance
rs58077086	9:86,465,131	T/C	—	benign
rs751037465	9:86,465,132	A/C	—	uncertain significance
rs1200882258	9:86,465,176	A/C	—	uncertain significance
rs9410888	9:86,465,402	G/A	intron variant	—
rs295273	9:86,466,968	G/A	intron variant	—
rs759556164	9:86,468,567	T/C	—	uncertain significance
rs909861058	9:86,468,570	T/C	—	likely benign
rs529481603	9:86,468,627	G/A	—	uncertain significance
rs773480141	9:86,468,666	G/A	—	uncertain significance
rs295274	9:86,468,715	A/T	—	benign
rs143915976	9:86,468,743	T/C	—	uncertain significance
rs167180	9:86,472,376	T/C	—	—
rs1181957780	9:86,474,101	T/G	—	uncertain significance
rs1157722863	9:86,474,110	C/A	—	likely benign
rs1429741091	9:86,474,112	C/A	—	uncertain significance
rs1178877821	9:86,474,114	T/A	—	uncertain significance
rs55654273	9:86,474,115	T/C	—	benign
rs746194165	9:86,474,116	G/T	—	uncertain significance
rs149424110	9:86,474,122	G/T	—	benign
rs144855861	9:86,474,123	C/T	—	uncertain significance
rs765041527	9:86,474,124	G/A	—	uncertain significance
rs74436006	9:86,474,167	T/C	—	benign
rs759346153	9:86,474,196	T/C	—	uncertain significance
rs767566638	9:86,474,199	T/C	—	uncertain significance
rs117193939	9:86,474,227	C/G	—	uncertain significance
rs139839095	9:86,474,230	C/G	—	uncertain significance
rs201841310	9:86,474,241	G/T	—	uncertain significance
rs146715557	9:86,474,252	C/A	—	uncertain significance
rs28712486	9:86,481,873	C/A	intron variant	—
rs1166245954	9:86,485,462	C/A	—	uncertain significance
rs775221357	9:86,485,525	T/C	—	uncertain significance
rs117807173	9:86,486,212	A/C	downstream gene variant	—
rs759775007	9:86,495,232	G/A	—	uncertain significance
rs767684781	9:86,495,253	G/T	—	uncertain significance
rs200952027	9:86,495,276	C/T	—	likely benign
rs754684305	9:86,495,285	C/G	—	uncertain significance
rs771377650	9:86,495,322	C/T	—	uncertain significance
rs374771696	9:86,498,790	T/C	—	uncertain significance
rs758953455	9:86,498,867	T/C	—	uncertain significance
rs202151820	9:86,498,927	T/G	—	uncertain significance
rs1365995874	9:86,501,963	T/C	—	uncertain significance
rs1952172059	9:86,501,979	A/T	—	uncertain significance
rs570677869	9:86,503,435	A/T	—	uncertain significance
rs114435432	9:86,503,468	A/T	—	benign
rs190657428	9:86,503,503	T/C	—	uncertain significance
rs13289566	9:86,504,005	C/T	—	benign
rs187689772	9:86,504,035	T/A	—	likely benign
rs2778373	9:86,504,508	A/G	intron variant	—
rs750925868	9:86,506,211	T/C	—	uncertain significance
rs140861753	9:86,506,236	T/C	—	uncertain significance
rs2490916960	9:86,506,377	G/C	—	uncertain significance
rs2490918744	9:86,506,399	T/G	—	uncertain significance
rs147660786	9:86,514,583	C/T	—	uncertain significance
rs1954099223	9:86,517,997	T/C	—	uncertain significance
rs199704500	9:86,518,190	C/T	—	likely benign
rs756890196	9:86,518,219	T/C	—	uncertain significance
rs41282417	9:86,518,285	A/C	—	uncertain significance
rs1284800216	9:86,518,291	G/A	—	uncertain significance
rs1362206149	9:86,518,317	G/C	—	uncertain significance
rs367896750	9:86,518,333	C/T	—	uncertain significance
rs2491273178	9:86,518,350	A/C	—	uncertain significance
rs754337057	9:86,518,441	G/T	—	uncertain significance
rs2491282149	9:86,518,489	A/G	—	uncertain significance
rs368536781	9:86,518,535	G/A	—	uncertain significance
rs2491291622	9:86,518,624	C/A	—	uncertain significance
rs141363838	9:86,518,672	G/A	—	uncertain significance
rs1280512260	9:86,518,732	C/T	—	uncertain significance
rs12001918	9:86,518,796	T/C	—	benign
rs767839569	9:86,518,818	G/C	—	uncertain significance
rs752861336	9:86,518,826	G/C	—	uncertain significance
rs540462841	9:86,518,919	T/G	—	uncertain significance
rs7869321	9:86,520,782	C/T	—	—
rs775041607	9:86,523,373	T/C	—	uncertain significance
rs140491572	9:86,523,409	T/C	—	likely benign
rs372555424	9:86,523,414	G/A	—	uncertain significance
rs766193831	9:86,523,489	C/T	—	uncertain significance
rs1398188008	9:86,530,214	T/C	—	uncertain significance
rs148934176	9:86,530,314	T/C	—	uncertain significance
rs761818271	9:86,530,381	A/C	—	uncertain significance
rs1955593908	9:86,530,391	A/G	—	uncertain significance

Showing 100 of 102 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.