KIF6
kinesin family member 6
Summary
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
Known Variants65 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs56370893 | 6:39,297,885 | G/A | 3 prime UTR variant | — |
| rs9471075 | 6:39,307,032 | A/C | intron variant | — |
| rs9471077 | 6:39,308,742 | A/G | intron variant | — |
| rs144156709 | 6:39,311,524 | C/T | — | uncertain significance |
| rs139582255 | 6:39,311,554 | C/T | — | likely benign |
| rs1050671338 | 6:39,313,536 | G/A | — | uncertain significance |
| rs944880180 | 6:39,313,551 | C/G | — | uncertain significance |
| rs9462535 | 6:39,315,792 | C/G | — | — |
| rs20455 | 6:39,325,078 | A/G | missense variant | drug response |
| rs368687338 | 6:39,328,242 | T/C | — | uncertain significance |
| rs188790180 | 6:39,330,237 | C/T | — | uncertain significance |
| rs78975723 | 6:39,338,990 | C/G | intron variant | — |
| rs9296295 | 6:39,361,854 | C/A | intron variant | — |
| rs144852615 | 6:39,366,992 | A/G | intron variant | — |
| rs1771119201 | 6:39,398,836 | T/G | — | uncertain significance |
| rs1185396153 | 6:39,398,853 | T/A | — | uncertain significance |
| rs1263125012 | 6:39,398,854 | C/A | — | uncertain significance |
| rs775249776 | 6:39,398,866 | C/T | — | uncertain significance |
| rs2481714797 | 6:39,398,883 | C/G | — | uncertain significance |
| rs374888397 | 6:39,398,893 | T/C | — | uncertain significance |
| rs751271999 | 6:39,398,929 | C/T | — | uncertain significance |
| rs9380862 | 6:39,404,162 | C/T | intron variant | — |
| rs527871768 | 6:39,419,992 | G/A | — | — |
| rs142407346 | 6:39,507,896 | G/A | — | uncertain significance |
| rs201826611 | 6:39,507,923 | G/C | — | uncertain significance |
| rs144652394 | 6:39,507,949 | G/T | — | uncertain significance |
| rs558073759 | 6:39,512,379 | C/T | — | uncertain significance |
| rs764028499 | 6:39,512,391 | A/C | — | uncertain significance |
| rs2482369276 | 6:39,512,415 | T/C | — | uncertain significance |
| rs755366325 | 6:39,512,418 | T/C | — | uncertain significance |
| rs746139660 | 6:39,512,457 | C/T | — | uncertain significance |
| rs1458196082 | 6:39,513,370 | G/T | — | uncertain significance |
| rs369041236 | 6:39,513,393 | A/G | — | uncertain significance |
| rs369914344 | 6:39,513,450 | A/G | — | uncertain significance |
| rs9380880 | 6:39,528,982 | G/C | — | — |
| rs4714259 | 6:39,536,576 | G/A | — | — |
| rs4714261 | 6:39,539,207 | C/T | intron variant | — |
| rs200447795 | 6:39,545,857 | C/T | — | uncertain significance |
| rs2482585691 | 6:39,545,863 | T/C | — | uncertain significance |
| rs376939652 | 6:39,552,729 | C/T | — | uncertain significance |
| rs764782635 | 6:39,554,087 | A/G | — | uncertain significance |
| rs36103565 | 6:39,554,126 | T/C | — | uncertain significance |
| rs755557178 | 6:39,554,149 | G/A | — | uncertain significance |
| rs372620767 | 6:39,563,874 | T/G | — | uncertain significance |
| rs145393659 | 6:39,563,955 | C/T | — | uncertain significance |
| rs765757861 | 6:39,563,971 | T/A | — | uncertain significance |
| rs763483672 | 6:39,563,975 | T/C | — | uncertain significance |
| rs199511584 | 6:39,563,988 | G/T | — | uncertain significance |
| rs750710755 | 6:39,563,997 | A/G | — | uncertain significance |
| rs141406865 | 6:39,564,011 | C/T | — | uncertain significance |
| rs200617438 | 6:39,564,023 | T/C | — | uncertain significance |
| rs200974739 | 6:39,581,030 | C/T | — | uncertain significance |
| rs772211358 | 6:39,581,059 | A/G | — | uncertain significance |
| rs1783322758 | 6:39,581,064 | C/A | — | uncertain significance |
| rs1224763328 | 6:39,581,081 | G/T | — | uncertain significance |
| rs549432952 | 6:39,590,690 | G/A | — | — |
| rs754642153 | 6:39,602,685 | T/C | — | uncertain significance |
| rs1561954518 | 6:39,682,489 | A/T | — | uncertain significance |
| rs150291005 | 6:39,682,502 | C/T | — | likely benign |
| rs1380155439 | 6:39,682,526 | C/A | — | uncertain significance |
| rs34059104 | 6:39,682,532 | T/C | — | likely benign |
| rs538661685 | 6:39,688,530 | G/T | — | uncertain significance |
| rs767694711 | 6:39,688,575 | C/A | — | uncertain significance |
| rs2481032540 | 6:39,693,032 | G/A | — | uncertain significance |
| rs776781970 | 6:39,693,071 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.