rs9471077
This is a intron variant variant in the KIF6 gene.
▶Research that mentions this SNP (1)
▶Genetic variants in the KIF6 region and coronary event reduction from statin therapyAssociationN=6,300Yonghong Li et al.(2011)· Human Genetics
Fine mapping study of the KIF6 region in three clinical trials (CARE, PROVE IT-TIMI22, WOSCOPS) identified three SNPs (rs20455/Trp719Arg, rs9462535, rs9471077) associated with differential coronary event reduction from statin therapy. Carriers of minor alleles showed 37-50% event reduction (OR/HR 0.50-0.67, p<0.01) while non-carriers showed no benefit. All three SNPs are in high linkage disequilibrium and also associated with coronary heart disease risk.
About KIF6
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
View all KIF6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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