KNDC1
kinase non-catalytic C-lobe domain containing 1
Summary
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Known Variants155 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1488194548 | 10:134,973,991 | C/A | — | uncertain significance |
| rs12765185 | 10:134,977,077 | T/A | intron variant | — |
| rs140318541 | 10:134,980,953 | C/T | — | likely benign |
| rs753883751 | 10:134,980,981 | C/T | — | uncertain significance |
| rs754953428 | 10:134,980,982 | G/A | — | likely benign |
| rs368273039 | 10:134,980,999 | G/T | — | uncertain significance |
| rs760388933 | 10:134,981,029 | G/A | — | uncertain significance |
| rs372002375 | 10:134,981,048 | C/T | — | uncertain significance |
| rs557644848 | 10:134,981,796 | G/A | — | uncertain significance |
| rs1591219711 | 10:134,981,952 | C/T | — | uncertain significance |
| rs1213576731 | 10:134,996,896 | G/A | — | uncertain significance |
| rs569932237 | 10:134,996,974 | G/A | — | likely benign |
| rs201851981 | 10:134,996,980 | C/G | — | uncertain significance |
| rs751249516 | 10:134,996,981 | G/A | — | uncertain significance |
| rs751668060 | 10:134,999,486 | G/A | — | uncertain significance |
| rs750643175 | 10:134,999,498 | C/T | — | uncertain significance |
| rs756563735 | 10:134,999,499 | G/A | — | uncertain significance |
| rs200080608 | 10:134,999,546 | G/A | — | uncertain significance |
| rs780846375 | 10:134,999,582 | G/C | — | uncertain significance |
| rs2540498526 | 10:134,999,622 | C/G | — | uncertain significance |
| rs202054271 | 10:134,999,711 | C/T | — | uncertain significance |
| rs752105461 | 10:134,999,712 | G/C | — | uncertain significance |
| rs755799594 | 10:134,999,720 | G/C | — | uncertain significance |
| rs116684467 | 10:134,999,738 | G/A | — | benign |
| rs35998551 | 10:134,999,869 | G/A | — | benign |
| rs759226210 | 10:134,999,874 | C/G | — | uncertain significance |
| rs777896770 | 10:134,999,888 | C/G | — | uncertain significance |
| rs757206268 | 10:134,999,894 | A/G | — | likely benign |
| rs201959912 | 10:134,999,921 | G/A | — | uncertain significance |
| rs1170069176 | 10:135,000,011 | C/T | — | uncertain significance |
| rs200234621 | 10:135,000,023 | G/A | — | uncertain significance |
| rs577654066 | 10:135,000,090 | G/A | — | uncertain significance |
| rs773005915 | 10:135,000,158 | G/C | — | uncertain significance |
| rs372254199 | 10:135,000,170 | G/A | — | likely benign |
| rs764339506 | 10:135,000,171 | C/T | — | uncertain significance |
| rs138441060 | 10:135,002,089 | G/A | — | uncertain significance |
| rs757892036 | 10:135,002,130 | G/A | — | likely benign |
| rs540675763 | 10:135,003,114 | T/C | — | uncertain significance |
| rs143362573 | 10:135,003,134 | G/A | — | uncertain significance |
| rs2540507070 | 10:135,003,146 | G/A | — | uncertain significance |
| rs2540516198 | 10:135,009,194 | C/G | — | uncertain significance |
| rs149749895 | 10:135,009,203 | G/A | — | likely benign |
| rs368205705 | 10:135,009,248 | C/T | — | uncertain significance |
| rs911322471 | 10:135,009,251 | A/G | — | uncertain significance |
| rs933695318 | 10:135,009,275 | A/G | — | uncertain significance |
| rs768586413 | 10:135,009,285 | G/A | — | uncertain significance |
| rs753918113 | 10:135,009,303 | C/T | — | uncertain significance |
| rs370092960 | 10:135,009,309 | C/T | — | uncertain significance |
| rs201954162 | 10:135,011,243 | G/A | — | uncertain significance |
| rs144248701 | 10:135,011,867 | G/A | — | likely benign |
| rs147794684 | 10:135,011,868 | G/T | — | uncertain significance |
| rs778034895 | 10:135,011,876 | G/A | — | uncertain significance |
| rs370453667 | 10:135,011,897 | G/A | — | likely benign |
| rs921149387 | 10:135,011,948 | T/C | — | uncertain significance |
| rs959413150 | 10:135,011,951 | G/A | — | uncertain significance |
| rs148998705 | 10:135,011,961 | A/G | — | uncertain significance |
| rs1854259008 | 10:135,011,978 | C/T | — | uncertain significance |
| rs750624756 | 10:135,011,982 | C/A | — | uncertain significance |
| rs370700626 | 10:135,011,990 | G/A | — | likely benign |
| rs1194960728 | 10:135,012,124 | C/T | — | likely benign |
| rs34482209 | 10:135,012,202 | C/T | — | benign |
| rs375314435 | 10:135,012,254 | G/A | — | uncertain significance |
| rs773948215 | 10:135,012,264 | A/G | — | uncertain significance |
| rs199517844 | 10:135,012,266 | C/T | — | benign |
| rs574241324 | 10:135,012,347 | G/C | — | uncertain significance |
| rs369712730 | 10:135,012,362 | G/A | — | uncertain significance |
| rs763268352 | 10:135,012,372 | C/T | — | likely benign |
| rs768194603 | 10:135,012,384 | C/T | — | uncertain significance |
| rs778395696 | 10:135,012,402 | G/A | — | uncertain significance |
| rs752606722 | 10:135,012,405 | C/T | — | uncertain significance |
| rs553286379 | 10:135,012,407 | G/A | — | uncertain significance |
| rs746956068 | 10:135,012,414 | C/T | — | uncertain significance |
| rs780204765 | 10:135,012,417 | T/A | — | uncertain significance |
| rs1341081021 | 10:135,012,418 | C/G | — | uncertain significance |
| rs761282775 | 10:135,012,437 | G/C | — | uncertain significance |
| rs752309326 | 10:135,012,452 | G/A | — | uncertain significance |
| rs2135997128 | 10:135,012,453 | A/C | — | uncertain significance |
| rs1444115267 | 10:135,012,455 | G/A | — | likely benign |
| rs560932020 | 10:135,012,457 | C/T | — | likely benign |
| rs200652032 | 10:135,012,471 | C/T | — | uncertain significance |
| rs371445862 | 10:135,012,482 | G/A | — | uncertain significance |
| rs1589760210 | 10:135,012,492 | A/C | — | uncertain significance |
| rs1267393313 | 10:135,012,500 | A/G | — | uncertain significance |
| rs778880228 | 10:135,012,539 | G/C | — | uncertain significance |
| rs2540524444 | 10:135,012,567 | C/G | — | uncertain significance |
| rs1358797761 | 10:135,012,590 | C/A | — | uncertain significance |
| rs199922097 | 10:135,012,612 | C/T | — | benign |
| rs770243792 | 10:135,012,623 | G/C | — | uncertain significance |
| rs372750618 | 10:135,012,627 | G/A | — | uncertain significance |
| rs760510911 | 10:135,012,647 | G/C | — | uncertain significance |
| rs544718343 | 10:135,012,653 | G/A | — | likely benign |
| rs780327916 | 10:135,012,662 | C/T | — | uncertain significance |
| rs1854295662 | 10:135,012,761 | C/G | — | uncertain significance |
| rs768455025 | 10:135,012,972 | C/G | — | uncertain significance |
| rs887053906 | 10:135,012,976 | G/A | — | uncertain significance |
| rs768705866 | 10:135,013,082 | A/G | — | uncertain significance |
| rs1041619421 | 10:135,013,097 | C/T | — | uncertain significance |
| rs753437659 | 10:135,013,886 | G/A | — | likely benign |
| rs869025238 | 10:135,013,889 | G/T | — | uncertain significance |
| rs1445640810 | 10:135,013,899 | C/T | — | uncertain significance |
Showing 100 of 155 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.