rs12765185
This is a intron variant variant in the KNDC1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
self reported educational attainment
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele A
OR 0.01
p 3.0e-8
N 1,131,881
Large GWAS
European
multisite chronic pain
Johnston KJA et al. “Genome-wide association study of multisite chronic pain in UK Biobank.” Plos Genetics 15(6):e1008164 (2019)
Allele T
OR 0.02
p 4.0e-8
N 387,649
Major Consortium StudyLarge GWAS
European
About KNDC1
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
View all KNDC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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