LATS2
large tumor suppressor kinase 2
Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Known Variants76 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9552315 | 13:21,547,984 | C/T | downstream gene variant | — |
| rs1204563100 | 13:21,549,024 | C/G | — | uncertain significance |
| rs756833597 | 13:21,549,039 | C/T | — | likely benign |
| rs905177711 | 13:21,549,055 | G/C | — | uncertain significance |
| rs776466850 | 13:21,549,115 | C/T | — | uncertain significance |
| rs56266495 | 13:21,549,171 | G/A | — | likely benign |
| rs757005967 | 13:21,549,179 | G/A | — | uncertain significance |
| rs149434310 | 13:21,549,239 | C/T | — | benign |
| rs1407685302 | 13:21,549,248 | G/A | — | uncertain significance |
| rs1268144053 | 13:21,549,287 | T/C | — | uncertain significance |
| rs1869542128 | 13:21,549,308 | C/T | — | uncertain significance |
| rs371266176 | 13:21,549,340 | G/A | — | uncertain significance |
| rs145604868 | 13:21,549,354 | G/A | — | benign |
| rs185845417 | 13:21,549,487 | T/C | — | likely benign |
| rs541259179 | 13:21,551,873 | C/T | — | — |
| rs1417615326 | 13:21,553,856 | G/A | — | uncertain significance |
| rs56244446 | 13:21,555,600 | T/C | — | benign |
| rs56364254 | 13:21,555,609 | G/A | — | benign |
| rs756027275 | 13:21,555,610 | C/T | — | uncertain significance |
| rs61745905 | 13:21,555,714 | G/C | — | benign |
| rs753361598 | 13:21,555,724 | C/T | — | uncertain significance |
| rs778450722 | 13:21,555,725 | G/A | — | uncertain significance |
| rs1221806563 | 13:21,555,731 | T/G | — | uncertain significance |
| rs535172813 | 13:21,556,730 | G/A | — | — |
| rs139454181 | 13:21,557,379 | G/C | — | benign |
| rs1869979862 | 13:21,557,382 | A/C | — | uncertain significance |
| rs1370656875 | 13:21,557,543 | C/T | — | uncertain significance |
| rs201894248 | 13:21,557,730 | C/T | — | likely benign |
| rs2480171 | 13:21,559,858 | T/C | intron variant | — |
| rs140665148 | 13:21,562,232 | C/T | — | benign |
| rs745371213 | 13:21,562,246 | C/A | — | uncertain significance |
| rs370604792 | 13:21,562,279 | C/A | — | uncertain significance |
| rs2500154271 | 13:21,562,310 | A/G | — | uncertain significance |
| rs61749292 | 13:21,562,317 | G/A | — | benign |
| rs139641767 | 13:21,562,362 | C/T | — | benign |
| rs1870265422 | 13:21,562,364 | G/A | — | uncertain significance |
| rs760674320 | 13:21,562,379 | G/A | — | uncertain significance |
| rs768093071 | 13:21,562,483 | G/A | — | uncertain significance |
| rs576274819 | 13:21,562,503 | G/A | — | likely benign |
| rs2500156634 | 13:21,562,514 | G/A | — | uncertain significance |
| rs930951720 | 13:21,562,516 | G/T | — | uncertain significance |
| rs762484566 | 13:21,562,576 | C/A | — | uncertain significance |
| rs116331282 | 13:21,562,626 | G/A | — | benign |
| rs2500158442 | 13:21,562,726 | G/A | — | uncertain significance |
| rs1870313574 | 13:21,562,739 | C/A | — | uncertain significance |
| rs115615162 | 13:21,562,761 | C/T | — | benign |
| rs202010116 | 13:21,562,766 | C/T | — | uncertain significance |
| rs369167901 | 13:21,562,785 | C/T | — | likely benign |
| rs758259741 | 13:21,562,898 | C/T | — | uncertain significance |
| rs762957882 | 13:21,562,978 | G/T | — | uncertain significance |
| rs370973977 | 13:21,562,990 | C/T | — | uncertain significance |
| rs375447416 | 13:21,562,991 | C/T | — | uncertain significance |
| rs779525816 | 13:21,563,000 | G/A | — | uncertain significance |
| rs2500161278 | 13:21,563,024 | C/T | — | uncertain significance |
| rs201011483 | 13:21,563,079 | C/A | — | benign |
| rs774128777 | 13:21,563,152 | G/A | — | uncertain significance |
| rs1407362044 | 13:21,563,155 | C/T | — | uncertain significance |
| rs754631706 | 13:21,563,171 | C/A | — | uncertain significance |
| rs765750027 | 13:21,563,172 | C/A | — | uncertain significance |
| rs758975100 | 13:21,563,180 | G/A | — | uncertain significance |
| rs2500164035 | 13:21,563,258 | G/A | — | uncertain significance |
| rs764530088 | 13:21,563,263 | A/G | — | uncertain significance |
| rs750461080 | 13:21,563,278 | T/C | — | uncertain significance |
| rs1307115431 | 13:21,563,342 | C/T | — | uncertain significance |
| rs375149933 | 13:21,563,363 | G/T | — | likely benign |
| rs1870496759 | 13:21,565,444 | G/T | — | uncertain significance |
| rs1199735 | 13:21,570,202 | G/C | downstream gene variant | — |
| rs673314 | 13:21,570,668 | C/G | — | — |
| rs12323020 | 13:21,570,912 | T/C | downstream gene variant | — |
| rs75604941 | 13:21,608,259 | C/T | regulatory region variant | — |
| rs9509492 | 13:21,608,971 | A/T | — | — |
| rs55842804 | 13:21,619,894 | G/A | — | uncertain significance |
| rs2500324994 | 13:21,619,946 | G/C | — | uncertain significance |
| rs1186725515 | 13:21,619,964 | G/A | — | uncertain significance |
| rs1390448330 | 13:21,620,054 | G/A | — | uncertain significance |
| rs369330158 | 13:21,620,094 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.