LGI4

leucine rich repeat LGI family member 4

Summary

Involved in regulation of myelination. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants91 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1435819:35,615,995C/T—benign
rs104869019:35,616,016G/A—benign
rs1108480019:35,616,086C/T—benign
rs382698919:35,616,087G/A—benign
rs36847959019:35,616,141G/A—uncertain significance
rs206512321119:35,616,151G/C—uncertain significance
rs76408749319:35,616,257T/A—uncertain significance
rs56839155019:35,616,298G/A—benign
rs1261014619:35,616,315G/A—benign
rs1261023419:35,616,316C/T—benign
rs20114442119:35,616,348C/T—uncertain significance
rs77951664319:35,616,397G/A—likely benign
rs14585659419:35,616,398T/A—uncertain significance
rs106479709419:35,616,410A/Tmissense variantpathogenic
rs1297626919:35,616,464G/C—benign
rs5879907119:35,616,545G/A—benign
rs1297841419:35,616,562C/G—benign
rs163245719:35,616,953T/C—benign
rs93708719:35,617,122A/G—benign
rs106479709519:35,617,169C/A—pathogenic
rs14898776919:35,617,187A/G—likely benign
rs206513611119:35,617,201G/T—likely pathogenic
rs97494017619:35,617,223G/T—uncertain significance
rs75419186319:35,617,261G/A—likely benign
rs131996919:35,617,270T/C—benign
rs7735756019:35,617,293C/T—benign
rs78121602319:35,617,294G/C—likely benign
rs74580570819:35,617,295G/A—uncertain significance
rs136626961619:35,617,320G/A—pathogenic
rs37382235819:35,617,378C/G—likely benign
rs140994285719:35,617,386G/A—uncertain significance
rs75039293419:35,617,434G/A—uncertain significance
rs120143096719:35,617,442A/T—likely pathogenic
rs206513957019:35,617,512C/T—likely pathogenic
rs138391064019:35,617,518C/T—uncertain significance
rs95236532019:35,617,539G/A—uncertain significance
rs127048681019:35,617,557T/C—uncertain significance
rs77599744619:35,617,610C/Tstop gainedpathogenic
rs87937503819:35,617,629C/G—uncertain significance
rs168799819:35,617,639C/G—benign
rs37694818219:35,617,678C/T—likely benign
rs160047020919:35,617,681T/C—uncertain significance
rs37062068019:35,617,750G/A—likely benign
rs106479709319:35,617,752C/G—pathogenic
rs77923298719:35,617,757C/Tmissense variantpathogenic
rs14207902519:35,617,773G/C—likely benign
rs75550059119:35,617,777C/Gmissense variantpathogenic
rs13869503119:35,617,784G/A—uncertain significance
rs206514335919:35,617,790G/C—uncertain significance
rs75857129019:35,617,791G/C—uncertain significance
rs36764896419:35,617,824G/A—likely benign
rs75410682019:35,617,836T/C—likely benign
rs37400785219:35,617,847T/C—uncertain significance
rs53766907919:35,617,918A/T—uncertain significance
rs1042060819:35,617,920C/T—benign
rs14636231919:35,620,113G/Adownstream gene variant—
rs77171942619:35,622,333C/A—uncertain significance
rs19966329219:35,622,361G/A—likely benign
rs19980673619:35,622,362C/T—likely benign
rs129066615119:35,622,364C/T—uncertain significance
rs20172819019:35,622,414C/G—conflicting classifications of pathogenicity
rs74801755719:35,622,423G/A—likely benign
rs54795904519:35,622,424C/T—uncertain significance
rs120756347919:35,622,425G/A—uncertain significance
rs55658086919:35,622,449C/T—uncertain significance
rs168800119:35,622,492C/T—benign
rs167300719:35,622,695G/A—benign
rs77373216319:35,622,717C/T—uncertain significance
rs37320629119:35,622,867G/A—likely benign
rs11704359119:35,624,548G/A—benign
rs251333009019:35,624,599G/T—likely pathogenic
rs14608858819:35,624,617G/T—benign
rs14850857219:35,624,632G/A—benign
rs1166657619:35,624,890C/T—benign
rs206519280119:35,624,937A/T—uncertain significance
rs155573493219:35,624,979A/C—likely pathogenic
rs3584964719:35,624,994G/A—benign
rs11181725019:35,625,318G/A—benign
rs37469260619:35,625,430G/A—uncertain significance
rs127133307519:35,625,441G/C—likely benign
rs15124007219:35,625,443C/T—likely benign
rs14061422919:35,625,524T/A—conflicting classifications of pathogenicity
rs15005195719:35,625,536C/T—uncertain significance
rs76830392819:35,625,538A/C—uncertain significance
rs75962793019:35,625,549A/C—likely benign
rs127602167819:35,625,568A/T—uncertain significance
rs120753436619:35,625,583A/G—pathogenic
rs15120750719:35,626,324T/G—benign
rs14038730619:35,626,325T/A—benign
rs244581719:35,626,349C/T—benign
rs245199119:35,626,373G/A—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.