LITAF

lipopolysaccharide induced TNF factor

Summary

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Known Variants240 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs7203193	16:11,641,180	A/C	—	—
rs760630375	16:11,641,614	T/C	—	uncertain significance
rs150472475	16:11,641,623	G/A	—	uncertain significance
rs759832566	16:11,641,640	T/C	—	likely benign
rs74808365	16:11,641,861	G/C	—	benign
rs62022848	16:11,641,866	C/T	—	benign
rs886051647	16:11,641,936	G/T	—	uncertain significance
rs77423500	16:11,642,000	A/C	—	benign
rs2064132273	16:11,642,057	A/C	—	uncertain significance
rs1005760992	16:11,642,071	T/C	—	uncertain significance
rs80119580	16:11,642,078	G/T	—	benign
rs774513067	16:11,642,094	G/T	—	uncertain significance
rs184312185	16:11,642,107	C/T	—	uncertain significance
rs775642546	16:11,642,129	T/G	—	uncertain significance
rs7102	16:11,642,242	C/T	—	benign
rs942172049	16:11,642,276	T/G	—	uncertain significance
rs886051648	16:11,642,323	T/C	—	uncertain significance
rs967890581	16:11,642,439	T/G	—	uncertain significance
rs886051649	16:11,642,544	T/C	—	uncertain significance
rs75472256	16:11,642,560	G/A	—	benign
rs192766322	16:11,642,589	C/T	—	benign
rs535657236	16:11,642,611	C/T	—	uncertain significance
rs7187810	16:11,642,677	A/T	—	benign
rs1198	16:11,642,697	G/A	—	benign
rs886051650	16:11,642,770	T/C	—	uncertain significance
rs117082330	16:11,642,782	C/A	—	benign
rs190484543	16:11,642,807	G/A	—	uncertain significance
rs367546754	16:11,642,895	C/T	—	uncertain significance
rs2064145331	16:11,642,930	T/G	—	uncertain significance
rs767760361	16:11,642,993	T/C	—	uncertain significance
rs192516633	16:11,643,040	G/T	—	benign
rs13337025	16:11,643,054	C/T	—	benign
rs13336723	16:11,643,072	G/A	—	benign
rs886051651	16:11,643,199	T/A	—	uncertain significance
rs1370604103	16:11,643,259	G/T	—	uncertain significance
rs886051652	16:11,643,300	C/T	—	uncertain significance
rs565356536	16:11,643,308	A/G	—	uncertain significance
rs1801977	16:11,643,350	G/A	—	benign
rs898867952	16:11,643,355	C/G	—	uncertain significance
rs1597324647	16:11,643,377	G/T	—	uncertain significance
rs149712652	16:11,643,394	G/A	—	likely benign
rs189101115	16:11,643,425	C/T	—	likely benign
rs768639690	16:11,643,445	G/A	—	uncertain significance
rs201429019	16:11,643,456	C/G	—	uncertain significance
rs766852963	16:11,643,460	C/T	—	uncertain significance
rs571908546	16:11,643,469	G/T	—	uncertain significance
rs2506541029	16:11,643,496	C/G	—	uncertain significance
rs376296739	16:11,643,498	A/G	—	likely benign
rs864622744	16:11,643,500	C/T	—	uncertain significance
rs748017885	16:11,643,501	G/A	—	conflicting classifications of pathogenicity
rs371453151	16:11,643,502	C/T	—	conflicting classifications of pathogenicity
rs772527709	16:11,643,506	T/C	—	uncertain significance
rs2506541390	16:11,643,509	G/C	—	uncertain significance
rs774123275	16:11,643,511	G/A	—	likely benign
rs2506541610	16:11,643,516	G/A	—	uncertain significance
rs760018833	16:11,643,521	G/A	—	uncertain significance
rs543022814	16:11,643,522	C/T	—	uncertain significance
rs897775080	16:11,643,529	G/C	—	uncertain significance
rs774258859	16:11,643,530	T/C	—	uncertain significance
rs764014476	16:11,643,531	T/G	—	uncertain significance
rs121908615	16:11,643,549	C/A	missense variant	uncertain significance
rs374918259	16:11,643,550	G/T	—	uncertain significance
rs1174214039	16:11,643,555	G/A	—	uncertain significance
rs750617013	16:11,643,559	G/A	—	likely benign
rs754821950	16:11,643,561	C/T	—	uncertain significance
rs2506542837	16:11,643,564	C/G	—	uncertain significance
rs780788687	16:11,643,567	C/T	—	conflicting classifications of pathogenicity
rs748118642	16:11,643,568	G/A	—	likely benign
rs144232569	16:11,643,569	C/T	—	uncertain significance
rs2064155943	16:11,643,570	A/G	—	uncertain significance
rs1057524422	16:11,643,571	G/T	—	uncertain significance
rs2141682435	16:11,643,572	A/G	—	uncertain significance
rs797044848	16:11,643,575	G/A	missense variant	uncertain significance
rs281865135	16:11,643,576	G/A	missense variant	uncertain significance
rs1012676457	16:11,643,580	G/A	—	likely benign
rs2506543486	16:11,643,587	C/T	—	uncertain significance
rs2141682573	16:11,643,590	C/G	—	uncertain significance
rs879254325	16:11,643,591	C/T	—	uncertain significance
rs777363288	16:11,643,592	C/T	—	likely benign
rs201512884	16:11,643,593	G/A	—	uncertain significance
rs797044847	16:11,643,594	C/T	missense variant	uncertain significance
rs867820855	16:11,643,597	T/C	—	uncertain significance
rs1183927285	16:11,643,598	G/A	—	likely benign
rs1597325058	16:11,643,599	C/T	—	uncertain significance
rs774213197	16:11,643,604	G/A	—	uncertain significance
rs969563231	16:11,643,608	G/A	—	conflicting classifications of pathogenicity
rs9936561	16:11,643,628	C/T	—	likely benign
rs9935945	16:11,643,631	G/A	—	benign
rs752383184	16:11,643,649	G/T	—	uncertain significance
rs79852290	16:11,643,727	G/A	—	benign
rs59139387	16:11,643,795	C/T	—	likely benign
rs75012078	16:11,643,856	G/A	—	benign
rs74469401	16:11,643,896	G/A	—	benign
rs11644920	16:11,645,013	A/T	intron variant	—
rs76278127	16:11,645,395	C/G	—	likely benign
rs7206280	16:11,645,520	C/A	—	benign
rs75642914	16:11,645,522	A/C	—	likely benign
rs1053595267	16:11,645,597	C/T	—	likely benign
rs61617938	16:11,645,626	T/C	—	benign
rs57456743	16:11,645,629	G/A	—	benign

Showing 100 of 240 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.