LNPEP
leucyl and cystinyl aminopeptidase
Summary
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants70 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2548225 | 5:96,273,033 | A/T | regulatory region variant | — |
| rs1046396 | 5:96,273,187 | G/A | upstream gene variant | — |
| rs2617439 | 5:96,275,154 | G/A | upstream gene variant | — |
| rs2432142 | 5:96,275,201 | G/A | upstream gene variant | — |
| rs7705093 | 5:96,290,647 | C/T | intron variant | — |
| rs2479343260 | 5:96,314,926 | G/A | — | uncertain significance |
| rs371113040 | 5:96,315,011 | G/A | — | uncertain significance |
| rs528454001 | 5:96,315,055 | G/A | — | uncertain significance |
| rs73775599 | 5:96,315,088 | G/A | — | uncertain significance |
| rs2479344038 | 5:96,315,117 | C/T | — | uncertain significance |
| rs772153884 | 5:96,315,159 | G/A | — | uncertain significance |
| rs774729202 | 5:96,315,200 | G/A | — | uncertain significance |
| rs753565895 | 5:96,315,241 | G/T | — | uncertain significance |
| rs747969232 | 5:96,315,256 | A/C | — | uncertain significance |
| rs374078966 | 5:96,315,265 | T/C | — | uncertain significance |
| rs752445811 | 5:96,315,414 | G/A | — | uncertain significance |
| rs2479345516 | 5:96,315,465 | A/T | — | uncertain significance |
| rs1790083092 | 5:96,315,558 | G/A | — | uncertain significance |
| rs770447013 | 5:96,315,621 | A/G | — | uncertain significance |
| rs776084384 | 5:96,315,627 | A/G | — | uncertain significance |
| rs748813298 | 5:96,315,634 | A/C | — | uncertain significance |
| rs10044354 | 5:96,320,495 | C/T | regulatory region variant | — |
| rs1443551004 | 5:96,320,816 | C/T | — | uncertain significance |
| rs38033 | 5:96,322,136 | A/G | intron variant | — |
| rs151314827 | 5:96,322,255 | G/A | — | likely benign |
| rs1392109129 | 5:96,322,282 | G/A | — | uncertain significance |
| rs766709145 | 5:96,322,342 | A/G | — | uncertain significance |
| rs377307978 | 5:96,322,349 | T/A | — | uncertain significance |
| rs75302290 | 5:96,328,765 | C/T | — | uncertain significance |
| rs1280972480 | 5:96,328,797 | T/C | — | uncertain significance |
| rs2479382342 | 5:96,329,525 | G/T | — | uncertain significance |
| rs777708122 | 5:96,329,563 | A/G | — | uncertain significance |
| rs543155083 | 5:96,329,584 | G/A | — | uncertain significance |
| rs759290846 | 5:96,329,667 | G/A | — | uncertain significance |
| rs444309 | 5:96,331,369 | C/G | — | — |
| rs430827 | 5:96,331,371 | A/C | regulatory region variant | — |
| rs750360079 | 5:96,333,740 | G/A | — | uncertain significance |
| rs1468767410 | 5:96,333,743 | T/G | — | uncertain significance |
| rs373856729 | 5:96,333,835 | C/T | — | uncertain significance |
| rs2479406016 | 5:96,339,120 | G/C | — | uncertain significance |
| rs200164948 | 5:96,339,241 | T/G | — | uncertain significance |
| rs27997 | 5:96,339,488 | G/T | intron variant | — |
| rs1477263944 | 5:96,341,817 | C/A | — | uncertain significance |
| rs746613270 | 5:96,341,826 | T/G | — | uncertain significance |
| rs760781173 | 5:96,341,893 | A/T | — | uncertain significance |
| rs2479413625 | 5:96,342,172 | G/A | — | uncertain significance |
| rs27289 | 5:96,346,278 | G/T | intron variant | — |
| rs27660 | 5:96,347,775 | C/T | — | — |
| rs148283748 | 5:96,349,361 | A/G | — | uncertain significance |
| rs2479431824 | 5:96,349,417 | A/G | — | uncertain significance |
| rs27291 | 5:96,350,270 | G/A | — | — |
| rs370258042 | 5:96,350,653 | G/T | — | uncertain significance |
| rs2479435676 | 5:96,350,696 | A/C | — | uncertain significance |
| rs2303138 | 5:96,350,710 | G/A | missense variant | — |
| rs376371115 | 5:96,350,779 | G/A | — | uncertain significance |
| rs149835144 | 5:96,350,797 | G/T | — | uncertain significance |
| rs27293 | 5:96,357,178 | A/T | — | — |
| rs27295 | 5:96,358,687 | C/T | intron variant | — |
| rs773449828 | 5:96,360,227 | T/C | — | uncertain significance |
| rs757072261 | 5:96,360,313 | A/G | — | uncertain significance |
| rs781319787 | 5:96,360,342 | A/G | — | uncertain significance |
| rs372486913 | 5:96,362,354 | C/G | — | uncertain significance |
| rs556954479 | 5:96,362,356 | G/A | — | uncertain significance |
| rs776988261 | 5:96,362,379 | A/G | — | uncertain significance |
| rs1791349279 | 5:96,362,401 | T/C | — | uncertain significance |
| rs1791382244 | 5:96,363,483 | A/G | — | uncertain significance |
| rs1421467056 | 5:96,364,106 | G/T | — | uncertain significance |
| rs761580978 | 5:96,364,145 | C/G | — | uncertain significance |
| rs1446568107 | 5:96,364,156 | T/G | — | uncertain significance |
| rs147001588 | 5:96,364,215 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.