rs27291

This variant is located in the LNPEP gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.07

p 5.0e-39

N 47,745

Large GWAS

European

complement C1q and tumor necrosis factor-related protein 9A measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.05

p 2.0e-25

N 47,745

Large GWAS

European

About LNPEP

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

rs27291

GWAS Catalog Trait Associations (2)

a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement

complement C1q and tumor necrosis factor-related protein 9A measurement

About LNPEP

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