LRRN2
leucine rich repeat neuronal 2
Summary
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3789045 | 1:204,586,812 | C/T | downstream gene variant | — |
| rs116599299 | 1:204,587,173 | G/C | — | uncertain significance |
| rs182204828 | 1:204,587,181 | G/A | — | uncertain significance |
| rs529295861 | 1:204,587,193 | G/A | — | uncertain significance |
| rs369330274 | 1:204,587,206 | C/T | — | uncertain significance |
| rs758864245 | 1:204,587,209 | C/T | — | uncertain significance |
| rs376037727 | 1:204,587,232 | C/A | — | uncertain significance |
| rs2527494061 | 1:204,587,425 | C/T | — | uncertain significance |
| rs77602548 | 1:204,587,443 | T/C | — | uncertain significance |
| rs754516595 | 1:204,587,476 | G/A | — | uncertain significance |
| rs778752230 | 1:204,587,481 | G/A | — | uncertain significance |
| rs762991312 | 1:204,587,506 | A/G | — | uncertain significance |
| rs766846193 | 1:204,587,527 | G/A | — | uncertain significance |
| rs3747631 | 1:204,587,569 | G/A | missense variant | — |
| rs558201537 | 1:204,587,697 | C/T | — | uncertain significance |
| rs995188006 | 1:204,587,761 | C/T | — | uncertain significance |
| rs376548384 | 1:204,587,830 | G/C | — | uncertain significance |
| rs138573874 | 1:204,587,841 | C/T | — | uncertain significance |
| rs754882816 | 1:204,587,880 | C/T | — | uncertain significance |
| rs200135141 | 1:204,587,895 | C/T | — | uncertain significance |
| rs141763834 | 1:204,587,896 | G/A | — | uncertain significance |
| rs115813868 | 1:204,587,927 | C/T | — | likely benign |
| rs771585869 | 1:204,587,973 | G/A | — | uncertain significance |
| rs777291049 | 1:204,588,127 | G/T | — | uncertain significance |
| rs1048645643 | 1:204,588,220 | T/C | — | uncertain significance |
| rs1396704602 | 1:204,588,285 | C/T | — | uncertain significance |
| rs774495531 | 1:204,588,306 | G/A | — | uncertain significance |
| rs780781216 | 1:204,588,370 | G/A | — | uncertain significance |
| rs201376768 | 1:204,588,434 | G/A | — | benign |
| rs143481345 | 1:204,588,474 | C/T | — | uncertain significance |
| rs141989916 | 1:204,588,493 | G/A | — | uncertain significance |
| rs773647972 | 1:204,588,573 | C/T | — | uncertain significance |
| rs138976383 | 1:204,588,574 | G/A | — | uncertain significance |
| rs200470325 | 1:204,588,658 | G/A | — | uncertain significance |
| rs34224191 | 1:204,588,668 | G/A | — | benign |
| rs2527501462 | 1:204,588,706 | C/T | — | uncertain significance |
| rs149594162 | 1:204,588,729 | C/T | — | uncertain significance |
| rs1268549809 | 1:204,588,767 | C/G | — | uncertain significance |
| rs749001330 | 1:204,588,772 | G/T | — | uncertain significance |
| rs144202788 | 1:204,588,859 | C/G | — | uncertain significance |
| rs367859771 | 1:204,588,880 | T/C | — | uncertain significance |
| rs770283181 | 1:204,588,903 | G/A | — | uncertain significance |
| rs746280603 | 1:204,588,978 | C/A | — | uncertain significance |
| rs918087646 | 1:204,588,987 | G/A | — | uncertain significance |
| rs200218737 | 1:204,588,988 | A/C | — | uncertain significance |
| rs759502182 | 1:204,588,991 | G/A | — | uncertain significance |
| rs58677547 | 1:204,650,529 | T/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.