LTF
lactotransferrin
Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]
Known Variants70 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs75094754 | 3:46,477,830 | C/T | intron variant | — |
| rs375151446 | 3:46,479,572 | A/G | — | uncertain significance |
| rs200727604 | 3:46,479,586 | T/C | — | likely benign |
| rs9110 | 3:46,480,801 | A/T | missense variant | — |
| rs145382222 | 3:46,480,815 | C/T | — | likely benign |
| rs749802528 | 3:46,480,830 | A/C | — | uncertain significance |
| rs144149027 | 3:46,480,854 | G/A | — | likely benign |
| rs750159077 | 3:46,480,869 | T/C | — | uncertain significance |
| rs139367879 | 3:46,480,909 | C/T | — | uncertain significance |
| rs1159715878 | 3:46,482,926 | A/G | — | likely benign |
| rs372826989 | 3:46,482,968 | C/G | — | likely benign |
| rs112990989 | 3:46,483,351 | G/A | intron variant | — |
| rs6441991 | 3:46,484,283 | T/C | — | — |
| rs775393601 | 3:46,484,933 | G/A | — | uncertain significance |
| rs1559594139 | 3:46,484,985 | A/C | — | uncertain significance |
| rs139298219 | 3:46,485,000 | G/A | — | likely benign |
| rs144111141 | 3:46,485,023 | G/A | — | uncertain significance |
| rs2528555377 | 3:46,485,043 | C/A | — | uncertain significance |
| rs7626288 | 3:46,485,369 | G/T | — | — |
| rs1462341921 | 3:46,486,780 | C/T | — | uncertain significance |
| rs150320764 | 3:46,486,793 | G/C | — | uncertain significance |
| rs147094293 | 3:46,486,841 | C/A | — | benign |
| rs545476834 | 3:46,486,912 | G/A | — | uncertain significance |
| rs61739313 | 3:46,487,937 | C/T | — | benign |
| rs1229558510 | 3:46,487,940 | G/T | — | uncertain significance |
| rs148398608 | 3:46,488,832 | A/G | — | uncertain significance |
| rs2528569103 | 3:46,488,889 | T/C | — | uncertain significance |
| rs1253218659 | 3:46,490,404 | C/T | — | uncertain significance |
| rs142586198 | 3:46,490,406 | C/A | — | uncertain significance |
| rs766474572 | 3:46,490,460 | A/G | — | uncertain significance |
| rs753146078 | 3:46,490,463 | G/A | — | uncertain significance |
| rs779678787 | 3:46,490,476 | C/A | — | uncertain significance |
| rs200930742 | 3:46,490,487 | C/G | — | uncertain significance |
| rs144305401 | 3:46,490,488 | G/A | — | uncertain significance |
| rs373296029 | 3:46,490,494 | C/T | — | uncertain significance |
| rs2106860280 | 3:46,490,498 | T/G | — | uncertain significance |
| rs755929107 | 3:46,491,371 | A/G | — | likely benign |
| rs200379115 | 3:46,491,493 | G/C | — | uncertain significance |
| rs61740470 | 3:46,491,985 | T/C | — | benign |
| rs144240700 | 3:46,492,103 | C/T | — | uncertain significance |
| rs772721698 | 3:46,492,111 | G/T | — | uncertain significance |
| rs34827868 | 3:46,493,855 | G/A | intron variant | — |
| rs761837195 | 3:46,495,825 | C/T | — | uncertain significance |
| rs763669047 | 3:46,496,788 | A/G | — | uncertain significance |
| rs542125560 | 3:46,496,863 | C/T | — | uncertain significance |
| rs557008950 | 3:46,496,880 | C/A | — | uncertain significance |
| rs145526650 | 3:46,496,910 | G/A | — | benign |
| rs148941436 | 3:46,497,312 | G/A | — | uncertain significance |
| rs1260895000 | 3:46,497,339 | C/T | — | uncertain significance |
| rs61740465 | 3:46,497,368 | G/T | — | benign |
| rs1330650728 | 3:46,497,403 | G/T | — | uncertain significance |
| rs371681789 | 3:46,497,424 | C/T | — | likely benign |
| rs145908484 | 3:46,497,802 | C/T | — | likely benign |
| rs1008316527 | 3:46,497,809 | A/G | — | uncertain significance |
| rs2528599017 | 3:46,497,813 | G/A | — | uncertain significance |
| rs185250935 | 3:46,499,544 | G/A | intron variant | — |
| rs765686239 | 3:46,501,147 | G/A | — | uncertain significance |
| rs773742721 | 3:46,501,151 | T/C | — | uncertain significance |
| rs141854619 | 3:46,501,168 | A/T | — | benign |
| rs768919985 | 3:46,501,207 | C/T | — | uncertain significance |
| rs776865450 | 3:46,501,208 | G/A | — | uncertain significance |
| rs191939074 | 3:46,501,260 | G/A | — | likely benign |
| rs563355635 | 3:46,501,265 | C/G | — | uncertain significance |
| rs17855462 | 3:46,501,292 | G/A | — | uncertain significance |
| rs4683234 | 3:46,501,769 | C/G | intron variant | — |
| rs36114837 | 3:46,505,315 | G/A | — | — |
| rs56233078 | 3:46,511,969 | G/A | intron variant | — |
| rs6762703 | 3:46,518,318 | T/G | intron variant | — |
| rs73067779 | 3:46,526,387 | C/T | intron variant | — |
| rs12637386 | 3:46,528,199 | G/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.