LY96
lymphocyte antigen 96
Summary
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11465996 | 8:74,901,962 | C/G | upstream gene variant | — |
| rs10086976 | 8:74,905,150 | C/T | intron variant | — |
| rs190231999 | 8:74,908,641 | T/A | — | — |
| rs4738413 | 8:74,915,934 | A/G | regulatory region variant | — |
| rs1358027228 | 8:74,917,054 | A/G | — | uncertain significance |
| rs6472812 | 8:74,917,084 | A/G | missense variant | — |
| rs17226566 | 8:74,919,912 | T/C | intron variant | — |
| rs2536430668 | 8:74,922,262 | A/C | — | uncertain significance |
| rs199845476 | 8:74,922,284 | C/T | — | uncertain significance |
| rs770987928 | 8:74,922,361 | G/A | — | uncertain significance |
| rs7007114 | 8:74,931,483 | T/A | intron variant | — |
| rs11466004 | 8:74,941,275 | C/T | missense variant | — |
| rs1054044936 | 8:74,941,276 | C/T | — | uncertain significance |
| rs116339495 | 8:74,958,249 | C/T | upstream gene variant | — |
| rs7001413 | 8:75,010,233 | G/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.