MAD2L2

mitotic arrest deficient 2 like 2

Summary

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

Known Variants105 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2521905708	1:11,734,834	A/G	—	uncertain significance
rs2100704674	1:11,734,839	C/A	—	uncertain significance
rs770656293	1:11,734,850	G/A	—	likely benign
rs753211809	1:11,734,851	C/T	—	uncertain significance
rs578142640	1:11,734,859	C/T	—	likely benign
rs757456103	1:11,734,861	C/T	—	uncertain significance
rs143263619	1:11,734,862	G/A	—	benign
rs373556198	1:11,734,878	C/T	—	likely benign
rs780068171	1:11,734,879	G/A	—	likely benign
rs770159498	1:11,735,119	C/T	—	likely benign
rs1260410848	1:11,735,129	C/T	—	likely benign
rs555143694	1:11,735,130	G/A	—	likely benign
rs141637184	1:11,735,151	C/T	—	benign
rs28924114	1:11,735,154	C/T	—	benign
rs779016176	1:11,735,180	G/A	—	uncertain significance
rs747572072	1:11,735,184	G/C	—	uncertain significance
rs1304537564	1:11,735,196	G/A	—	likely benign
rs1255492563	1:11,735,214	C/T	—	likely benign
rs2521908523	1:11,735,226	G/A	—	likely benign
rs769098201	1:11,735,235	G/A	—	likely benign
rs2521908636	1:11,735,244	C/T	—	likely benign
rs878778	1:11,735,245	A/C	—	benign
rs202001059	1:11,735,246	A/C	—	likely benign
rs1189463377	1:11,735,705	C/A	—	likely benign
rs2521911562	1:11,735,711	T/G	—	uncertain significance
rs2521911653	1:11,735,737	A/G	—	uncertain significance
rs1369120504	1:11,735,744	G/A	—	uncertain significance
rs766668415	1:11,735,750	C/T	—	uncertain significance
rs776999328	1:11,735,751	G/A	—	likely benign
rs2521911733	1:11,735,752	G/A	—	uncertain significance
rs2521911745	1:11,735,754	T/A	—	uncertain significance
rs139303308	1:11,735,761	G/T	—	uncertain significance
rs1380062220	1:11,735,766	C/A	—	likely benign
rs530535641	1:11,735,787	G/A	—	likely benign
rs2521911949	1:11,735,790	T/C	—	uncertain significance
rs1237684412	1:11,735,796	G/A	—	likely benign
rs375506566	1:11,735,797	G/A	—	likely benign
rs745917324	1:11,736,084	G/A	—	likely benign
rs769764556	1:11,736,086	G/A	—	likely benign
rs761716384	1:11,736,096	G/A	—	likely benign
rs771958137	1:11,736,101	A/T	—	uncertain significance
rs2233020	1:11,736,131	G/A	—	benign
rs764536092	1:11,736,137	G/A	—	likely benign
rs542007676	1:11,736,176	A/T	—	uncertain significance
rs756203983	1:11,736,187	G/A	—	likely benign
rs2521914758	1:11,736,192	T/G	—	uncertain significance
rs779137723	1:11,736,210	G/C	—	likely benign
rs747871567	1:11,736,212	A/G	—	likely benign
rs2336030	1:11,736,600	C/T	downstream gene variant	—
rs559644551	1:11,736,885	G/A	—	likely benign
rs2521918977	1:11,736,894	G/C	—	uncertain significance
rs1179078107	1:11,736,908	A/G	—	uncertain significance
rs1423704128	1:11,736,919	T/C	—	likely benign
rs754384497	1:11,736,943	G/A	—	likely benign
rs759600891	1:11,736,958	G/A	—	likely benign
rs151024263	1:11,736,959	C/A	—	uncertain significance
rs367637499	1:11,736,960	G/A	—	uncertain significance
rs778083174	1:11,736,963	G/A	—	uncertain significance
rs751276389	1:11,736,965	T/C	—	uncertain significance
rs1057517674	1:11,736,983	A/T	missense variant	pathogenic
rs1220087698	1:11,737,000	A/T	—	uncertain significance
rs763237071	1:11,737,010	A/G	—	benign
rs371928795	1:11,737,016	A/G	—	likely benign
rs768144340	1:11,737,022	C/T	—	likely benign
rs368998137	1:11,737,593	C/T	—	likely benign
rs1266788592	1:11,737,608	G/A	—	likely benign
rs1640792495	1:11,737,615	C/T	—	likely benign
rs1570286418	1:11,737,618	G/A	—	likely benign
rs373270586	1:11,737,621	G/A	—	likely benign
rs147937370	1:11,737,629	G/A	—	likely benign
rs377687352	1:11,737,631	G/A	—	uncertain significance
rs140482494	1:11,737,657	C/T	—	likely benign
rs2521923891	1:11,737,675	C/T	—	likely benign
rs2521923901	1:11,737,678	A/G	—	likely benign
rs760533952	1:11,737,687	T/C	—	likely benign
rs568513319	1:11,737,690	G/A	—	likely benign
rs1048106379	1:11,740,391	G/T	—	likely benign
rs2521936412	1:11,740,395	T/C	—	likely benign
rs531548339	1:11,740,398	G/A	—	likely benign
rs201210724	1:11,740,402	T/C	—	likely benign
rs765974447	1:11,740,410	C/T	—	uncertain significance
rs2521936591	1:11,740,424	T/C	—	uncertain significance
rs371290479	1:11,740,431	C/T	—	benign
rs999467395	1:11,740,436	G/A	—	uncertain significance
rs1309224638	1:11,740,440	C/T	—	likely benign
rs146185443	1:11,740,454	C/A	—	uncertain significance
rs759283688	1:11,740,455	G/A	—	likely benign
rs532070176	1:11,740,461	G/A	—	likely benign
rs1570290128	1:11,740,479	G/A	—	likely benign
rs1296763654	1:11,740,499	C/G	—	uncertain significance
rs2521937190	1:11,740,512	G/A	—	likely benign
rs1199952278	1:11,740,521	G/A	—	likely benign
rs771235981	1:11,740,534	G/A	—	likely benign
rs2233015	1:11,740,535	G/C	—	likely benign
rs373741421	1:11,740,536	G/T	—	likely benign
rs750057718	1:11,740,540	C/T	—	likely benign
rs778453767	1:11,740,548	G/A	—	likely benign
rs766995102	1:11,740,600	G/A	—	likely benign
rs760293423	1:11,740,626	A/G	—	likely benign
rs752166135	1:11,740,646	T/C	—	uncertain significance

Showing 100 of 105 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.