rs878778

This variant is located in the MAD2L2 gene.

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ClinVar annotation

Benign★☆☆☆

2 submitters1 publication

not provided; Hepatocellular carcinoma; Nonpapillary renal cell carcinoma; Ovarian cancer; Uterine corpus endometrial carcinoma; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Familial pancreatic carcinoma; Malignant lymphoma, large B-cell, diffuse; Uterine carcinosarcoma; Acute myeloid leukemia; Sarcoma; Lymphoma; Cholangiocarcinoma

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About MAD2L2

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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