MAP2K3

mitogen-activated protein kinase kinase 3

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Known Variants44 total

rsidPosition (GRCh37)AllelesClassClinVar
rs807615417:21,201,719T/C—benign
rs14843592317:21,201,750A/C—benign
rs7706653817:21,201,791C/T—likely benign
rs3391121817:21,202,191C/A—benign
rs18794678017:21,202,228T/C—benign
rs3604703517:21,202,237G/C—benign
rs3410530117:21,203,893T/C—benign
rs7331153917:21,203,907T/C—likely benign
rs6205767217:21,203,934G/A—likely benign
rs230587317:21,203,941G/A—benign
rs53030295517:21,203,946G/C—uncertain significance
rs6205767317:21,203,949C/T—likely benign
rs3607676617:21,203,961G/A—benign
rs6205772117:21,205,460C/T—likely benign
rs77248500517:21,205,528A/G—uncertain significance
rs52976818117:21,205,553T/C—benign
rs14139063117:21,205,561T/C—likely benign
rs374422217:21,206,440C/T——
rs73610317:21,206,556C/T—benign
rs13891725317:21,207,792A/T—likely benign
rs14283754817:21,207,796T/C—benign
rs7457590417:21,207,813T/G—uncertain significance
rs14357505717:21,207,829C/T—benign
rs5860946617:21,207,834C/T—benign
rs13959428917:21,207,838G/C—likely benign
rs223043617:21,207,844C/T—likely benign
rs14861200517:21,208,397G/T—benign
rs165769517:21,208,413C/T—likely benign
rs15061394217:21,208,417G/A—likely benign
rs143303647917:21,208,439T/C—uncertain significance
rs165769417:21,208,449G/T—benign
rs1165005317:21,212,820G/A——
rs990936217:21,215,204C/T——
rs6205536317:21,215,446C/T—benign
rs5593575717:21,215,483C/T—likely benign
rs15133866717:21,215,498C/G—benign
rs5573647417:21,215,537C/A—likely benign
rs5636973217:21,215,552C/T—likely benign
rs3520613417:21,215,557G/A—benign
rs76895136417:21,215,587C/T—uncertain significance
rs165768817:21,216,846G/C—likely benign
rs11671546817:21,217,476C/A—benign
rs3575574317:21,217,496C/T—uncertain significance
rs236319817:21,217,513G/A—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.